Pyrosequencing of the BRAFV600E Mutation

Thyroid Neoplasms Clinical Trial

Official title:

Diagnostic Value of Pyrosequencing for the BRAFV600E Mutation in Ultrasound-Guided Fine-Needle Aspiration Biopsy Samples of Thyroid Incidentalomas

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00551486
• Other study ID #: 071027
• Status: Completed
• Phase: N/A
• First received: October 30, 2007
• Last updated: October 30, 2007
• Start date: June 2006
• Est. completion date: December 2006

Study information

• Verified date: October 2007
• Source: Chungnam National University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

To investigate the diagnostic efficiency of pyrosequencing for the mutant BRAF allele in ultrasound (US)-guided fine needle aspiration biopsies (FNAB) of thyroid incidentalomas.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 101
• Est. completion date: December 2006
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

• Patients with thyroid nodule larger than 1 cm, or nodule smaller than 1 cm that required further evaluation because of suspicious ultrasound findings

Exclusion Criteria:

• Patients who refuse participation.

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Thyroid Neoplasms

Intervention

Procedure:
• ultrasound-guided fine needle aspiration biopsy
Fine needle aspiration (FNA)with cytologic analysis has become a mainstay of thyroid nodule evaluation was used. Nonpalpable nodules were aspirated under ultrasound guidance to facilitate precise targeting of the nodule and to sample the part most likely to improve diagnostic yield.

Locations

Country	Name	City	State
Korea, Republic of	Chungnam National University Hospital	Daejeon

Sponsors (1)

Lead Sponsor	Collaborator
Chungnam National University

Country where clinical trial is conducted

Korea, Republic of,