Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules

Thyroid Gland Nodule Clinical Trial

Official title:
Retrospective-Prospective Collection of Thyroid Specimens After FNA

Status Withdrawn

Clinical Trial Summary

This trial studies how well the diagnostic deoxyribonucleic acid (DNA) methylation signature works in detecting thyroid cancer in patients with thyroid nodules. Using diagnostic testing, such as the diagnostic DNA methylation signature, may be a less invasive way to check for thyroid cancer.

Clinical Trial Description

PRIMARY OBJECTIVES: I. To validate a novel epigenetic thyroid nodule diagnostic test, diagnostic DNA methylation signature (DDMS) in a retrospective-prospective study with leftover of fine needle aspiration biopsies. OUTLINE: Previously collected FNA aspiration specimen samples are analyzed via DDMS assay. Participants undergo FNA aspiration for collection of tissue samples for analysis via DDMS assay. After completion of study, patients are followed up yearly for 5 years. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03676647
Study type	Observational
Source	City of Hope Medical Center
Contact
Status	Withdrawn
Phase
Start date	June 1, 2023
Completion date	December 31, 2023

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See also
Status	Clinical Trial	Phase
Completed	`NCT03174925` - Ultrasound Elastography in Imaging Patients With Thyroid Nodules	N/A
Suspended	`NCT04742608` - Development of Liquid Biopsy Technologies for Noninvasive Cancer Diagnostics in Patients With Suspicious Thyroid Nodules or Thyroid Cancer
Recruiting	`NCT05003856` - Radiofrequency Ablation for the Treatment of Benign or Low Risk Thyroid Nodule	N/A