Study of Thyroid Status in Patients With IBD

Thyroid Disease Clinical Trial

Official title:

Study of Thyroid State in Patients With Inflammatory Bowel Diseases

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05542368
• Other study ID #: thyroid state in IBD patients
• Status: Not yet recruiting
• Start date: December 2022
• Est. completion date: December 2024

Study information

• Verified date: September 2022
• Source: Assiut University
• Contact: Hassan, Resident
• Phone: +201144971296
• Email: nisreenhassan6[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

. The aim of the present study is to study thyroid state in patients with IBD

Description:

All patients were subjected to history taking and physical examination with emphasis on history of autoimmune disease, extraintestinal manifestations of IBD, neck examination for goiter, symptoms and signs of thyroid dysfunction.

b) Laboratory investigations: Thyroid function test (include T3-T4- TSH)

• ESR - CRP - thyroid antibodies: (Anti TPO -Anti Thyroglobulin)

c)-Imaging:

• Neck U/S on thyroid gland to identify patients with ultrasonographic evidence of autoimmune thyroiditis (diffuse hypoechogenicity or heterogenicity echotexture or both) and to detect thyroid nodularity.

d ) Endoscopic findings regarding diagnosis of IBD confirmed by histopathological examination

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 90
• Est. completion date: December 2024
• Est. primary completion date: December 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria: All patients with IBD

-

Exclusion Criteria:

• patients with

• Thyroid disease

• Acute or chronic kidney

• Acute or Chronic Liver Disease. Active Lupus -

• Malignancy

• patients taking medications that affect thyroid function as rifampin, amiodarone …..

Related Conditions & MeSH terms

• Intestinal Diseases
• Irritable Bowel Disease
• Irritable Bowel Syndrome
• Thyroid Disease
• Thyroid Diseases

Intervention

Diagnostic Test:
• Thyroid tests
Thyroid function test TSH ,T3,T4 Thyroid antibody test anti TPO,antithyroglobulin

Locations

Country	Name	City	State
Egypt	Assiut University	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of thyroid disorders in patients with IBD	By use of Thyroid function test (include T3-T4- TSH), thyroid antibodies and thyroid sonography	1 year

External Links

•   Autoimmune thyroid disease (Graves' disease and hashimoto's thyroiditis) in two patients with Crohn's disease: case reports and literature review
•   Coexistence of Addison's disease, ulcerative colitis, hypothyroidism and pernicious anemia
•   Medical records of patients with ulcerative colitis (n= 858), Crohn's disease (n= 378) and coeliac disease (n = 148) were examined to determine the prevalence of associated autoimmune disorders.
•   nflammatory bowel disease severity and activity are correlated to thyroid gland nodularity, chronic nonthyroidal illness, and thyroid autoantibodies but not thyroid dysfunction
•   Role of autoantibodies in the pathogenesis and association of endocrine autoimmune disorders
•   Simultaneous occurrence of inflammatory bowel disease and thyroid disease
•   The prevalence of hyper- and hypothyroidism in patients with ulcerative colitis
•   Two cases of coexisting ulcerative colitis and hyperthyroidism are discussed