Comparison DW-MRI vs FDG PET/CT in the Detection of Early Recurrence of Cervical Well-differentiated Thyroid Carcinoma — THYRIRMTEP  

Thyroid Cancer Clinical Trial

Official title: Preliminary Study of the Interest of Diffusion-weighted Magnetic Resonance Imaging in the Early Detection of Differentiated Thyroid Carcinoma Cervical Recurrence. Comparison with18F-FDG PET/CT

Status Completed

Clinical Trial Summary

The purpose of the study is to evaluate the concordance between the 18F-PET/CT under thyrotropin stimulation and the diffusion-weighted Magnetic Resonance Imaging, in the detection of residual mass in 40 patients with partial response or relapsed differentiated thyroid carcinoma.

Clinical Trial Description

The schedule and the procedures of the study are the following ones :

• Baseline evaluation :

• Clinical examination with neck echography after rhTSH stimulation

• Normal whole body scan

• First visit (inclusion):

18F-FDG PET/CT DW-MRI of the neck if possible performed shortly after the PET CT or within following days

• Following visits: at 6 months and 12 months

• DW-MRI of the neck performed shortly after the PET CT or within following days.

• Ultrasonography guided fine needle aspiration for cytology for detection of cervical metastases and identifying thyroglobuline in the needle washout fluid if needed and in case of positivity of either PET or DW-MRI exams.

• Histological assessment of biopsies if performed ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Recurrence
• Relapse
• Thyroid Cancer
• Thyroid Diseases
• Thyroid Neoplasms

• NCT number: NCT02515084
• Study type: Interventional
• Source: Centre Henri Becquerel
• Status: Completed
• Phase: Phase 2
• Start date: March 2011
• Completion date: July 2016