Thymoma Clinical Trial
Official title:
Chemokine Receptor CXCR4-targeting PET Imaging for Thymoma
Chemokine receptor CXCR4 was expressed in T cells and CXCR4-targeting molecular imaging- 68Ga-Pentixafor PET/CT could be a promising technique to evaluate the extent of thymoma with higher accuracy. This prospective study is going to investigate whether metabolic characterization by 68Ga-Pentixafor PET/CT may be superior for diagnosis, distinguish evaluation for thymoma.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - suspected or confirmed untreated thymoma patients - signed written consent. Exclusion Criteria: - pregnancy - breastfeeding - known allergy against Pentixafor - any medical condition that in the opinion of the investigator,may - significantly interfere with study compliance. |
Country | Name | City | State |
---|---|---|---|
China | Peking Union Medical College Hospitall, Chinese Academy of Medical Science and Peking Union Medical College | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Peking Union Medical College Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | SUVmax and SUVmean | SUVsof focal lesions are measured on 68Ga-Pentixafor PET/CT. The SUVs of the blood pool and muscle are defined as the background activity on the condition that there is no focally hypermetabolic disease. | through study completion, an average of 1.5 years | |
Secondary | Diagnostic value | Diagnostic value of 68Ga-Pentixafor PET/CT for thymoma in comparison with 18F-FDG PET/CT or CT or MRI. | through study completion, an average of 1.5 years | |
Secondary | Diagnostic value in special type of thymoma | Diagnostic value of 68Ga-Pentixafor PET/CT in special type thymoma (A\AB\B\C subtypes) | through study completion, an average of 1.5 years | |
Secondary | Diagnostic value in thymoma and other masses | Diagnostic value of 68Ga-Pentixafor PET/CT in thymoma and other anterior mediastinal mass. | through study completion, an average of 1.5 years | |
Secondary | CXCR4 expression and SUV | Correlation between CXCR4 expression and SUV in PET | through study completion, an average of 1.5 years |
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