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Clinical Trial Summary

Chemokine receptor CXCR4 was expressed in T cells and CXCR4-targeting molecular imaging- 68Ga-Pentixafor PET/CT could be a promising technique to evaluate the extent of thymoma with higher accuracy. This prospective study is going to investigate whether metabolic characterization by 68Ga-Pentixafor PET/CT may be superior for diagnosis, distinguish evaluation for thymoma.


Clinical Trial Description

Thymoma is 1 rare type of tumor developed on the thymic epithelium; patients with thymoma also might have myasthenia gravis (MG). Because of the scarcity and complexity of MG-associated thymoma, its pathogenesis and etiology still remain unclear nowadays. The expression of C-X-C chemokine receptor type 4 (CXCR4) is absent or low in most healthy tissues but highly expressed in various types of tumors. CXCR4 might contribute to the clinical cancer progression, and CXCR4 could be a valuable prognostic biomarker in the therapy of MG-associated thymoma. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06086327
Study type Interventional
Source Peking Union Medical College Hospital
Contact Rongxi Wang
Phone +8615584172170
Email zhzwrx.123@163.com
Status Recruiting
Phase Early Phase 1
Start date June 22, 2023
Completion date December 31, 2024

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