Thymoma Clinical Trial - Relationship Between Computed Tomography

Status Completed

Clinical Trial Summary

the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

Clinical Trial Description

1. Introduction: the World Health Organization (WHO) has proposed a classification of histopathological thymic tumor and it significance in prognosis. Chest computed tomography (CT) is the most common method to evaluate thymic epithelial tumors before operation. Therefore, the question is to predict the histopathological type of thymic epithelial tumors before surgery based on CT-scan images , to help determine treatment strategy and prognosis. In Vietnam, there are no published literature on this issue.

2. Materials and methods:

2.1. Cross-sectional descriptive study on 53 patients with diagnosed of thymoma by CT and had postoperative histopathology results as thymic epithelial tumors

2.2. Time and Place: in Departement of CTVS, Military Hospital 103, Vietnam from 10/2013 to 7/2017.

2.3. methods:

- study in chest CT scan:

- Measure the maximun diameter of the tumor

- The contour: smooth contour or irregular contour

- The shape: round, oval and plaque base on the ratio between long axis and short axis of the tumor

- Some other characteristics: Degree of enhancement, Level of drug absorbed, Calcification, Invasion the local organs and Capsular destruction.

- Histopathological study: based on the 2004 WHO classification:

- Thymoma: type A, AB, B1, B2, B3

- Thymic carcinoma

- Data processing: use software Epi Info 2000.

3. Expectation of results

- Relationship between the size and histopathological type of thymic epithelial tumors.

- Comparison of some characteristics of the tumor on preoperative chest CT scans and histopathological type of thymic epithelial tumors ;

Study Design

Related Conditions & MeSH terms

Neoplasms, Glandular and Epithelial
Thymoma
Thymus Neoplasms

Clinical Trial Details

NCT number	NCT03288662
Study type	Interventional
Source	Military Hospital 103
Contact
Status	Completed
Phase	N/A
Start date	October 1, 2013
Completion date	July 31, 2017

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms