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Clinical Study of Postoperative Carbon Ion Radiotherapy for Thymus Tumor With Residual Tumor

Radiotherapy Side Effect Clinical Trial

Official title:
Prospective Phase II Clinical Study of Postoperative Carbon Ion Radiotherapy for Thymic Epithelial Malignant Tumor Received R2 Resection

Clinical Trial Summary

To observe the efficacy and toxicities of heavy ion radiation therapy for locally advanced or advanced primary thymic epithelial malignant tumor received R2 resection. The primary endpoint was progression-free survival and toxicities, and the secondary endpoint was local relapse-free survival, overall survival and cause-specific survival.

Clinical Trial Description

The patients will receive 72GyE per 18 fractions of carbon ion radiotherapy. Patients with thymus cancer should be combined with platinum-based regimen (including etoposide combined with cisplatin / carboplatin / loplatin / nedaplatin; paclitaxel combined with cisplatin or cisplatin / carboplatin / loplatin / nedaplatin; docetaxel combined with cisplatin / carboplatin / loplatin / nedaplatin) for at least 4 cycles. The primary endpoint was progression-free survival and toxicities, and the secondary endpoint was local relapse-free survival, overall survival and cause-specific survival. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06311955
Study type Interventional
Source Shanghai Proton and Heavy Ion Center
Contact Jing Li
Phone 86-21-38296678
Email jing.li@sphic.org.cn
Status Recruiting
Phase Phase 2
Start date April 1, 2024
Completion date February 28, 2029
View Details
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