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Thumb Osteoarthritis clinical trials

View clinical trials related to Thumb Osteoarthritis.

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NCT ID: NCT06401317 Not yet recruiting - Clinical trials for Thumb Osteoarthritis

Corticosteroid Against Saline Injections for Thumb Osteoarthritis (CASITOA)

CASITOA
Start date: September 1, 2024
Phase: N/A
Study type: Interventional

Thumb osteoarthritis or trapeziometacarpal osteoarthritis (TMO) is a common and painful form of hand arthritis that limits thumb mobility and hand function, affecting patients' quality of life. Although corticosteroids injections are a typical treatment, their effectiveness has been challenged, and side effects have been reported. Recent studies suggest that saline injections, usually considered inactive, might be a viable treatment option. The primary goal of this study is to compare the effectiveness of saline injections versus corticosteroids injections in reducing TMO-related pain and improving hand function. In this study, 40 people with TMO will be randomly assigned to receive either a corticosteroids or a saline injection, without them or the doctors performing the injection knowing which one was administered (double blind). If saline injections prove more effective, they could provide a less harmful and cheaper therapeutic alternative for TMO patients.

NCT ID: NCT06056765 Recruiting - Hand Injuries Clinical Trials

Extracorporeal Shock Waves Therapy (ESWT) vs Exercise in Thumb Osteoarthritis

SWEX-TO
Start date: January 1, 2024
Phase: N/A
Study type: Interventional

Osteoarthritis (OA) is a chronic joint disease with a high prevalence and a negative impact on the quality of life and a high economic burden. The most common form of OA is that involving the hands, which affects females three times more often. OA of the base of the first finger is present in 21% of the population over 40 years of age and is more frequently related to pain and disability than OA of the interphalangeal joint. In addition to pain, it can cause deformity, stiffness, reduced mobility and strength, resulting in difficulty performing common activities such as opening vessels, carrying weights and writing. OA of the base of the first toe is mainly treated with conservative modalities, while surgical treatment will be reserved for those whose debilitating symptoms persist despite adequate conservative management. Surgical management, however, is associated with a number of complications, including tendon rupture, sensory changes, and wound infection. Although a number of conservative therapies have proven effective for the management of hand OA, there are few high-quality clinical studies in the literature to date.

NCT ID: NCT05992883 Recruiting - Clinical trials for Thumb Osteoarthritis

NSAID Injection Versus Corticosteroid Injection for Basilar Thumb Arthritis

Start date: July 28, 2023
Phase: Phase 3
Study type: Interventional

The Researchers are trying to compare two different types of intraarticular injections (injection in the joint) for treating the symptoms of moderate to advanced basilar thumb arthritis. One injection is ketorolac (an NSAID) and the other is triamcinolone (a corticosteroid).

NCT ID: NCT05896410 Not yet recruiting - Clinical trials for Thumb Osteoarthritis

3D-Printed Hand Orthosis Versus Thermoplastic Orthosis

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This study will investigate the effectiveness of 3D-printed splints for treating thumb osteoarthritis (CMC OA). These splints are made by Occupational Therapists and Physical Therapists out of low-temperature plastic and formed on the patient's hand. 3D printed splints involve photographing the hand and creating a digital file of the splint. This is then printed and fit on the patient. The goal of this cross-over clinical trial is to compare the effectiveness of 3D-printed splints versus thermoplastic splints for treating thumb osteoarthritis (CMC OA). The main question[s] it aims to answer are: Primary objective: • Evaluate the general useability and possible benefits of splint production by 3D printing in a clinical setting Secondary objectives: - Compare the effectiveness of 3D printed orthosis and the low-temperature plastic fabrication manual method in pain reduction - Compare the effectiveness of 3D printed orthosis and the low-temperature plastic fabrication manual method in improving the function. - Compare the satisfaction of patients with the 3D printed orthosis and low-temperature plastic fabrication manual method. - Compare the length of time needed to fabricate each orthosis - Compare the weight of orthosis Participants will provide with two splints (traditional orthosis and 3D-printed orthoses). Participants will use the first orthosis for three weeks, be given a week for washout, and then cross over to the second orthosis.

NCT ID: NCT05772715 Completed - Clinical trials for Thumb Osteoarthritis

The THumb Osteoarthritis Exercise TriAl

THETA
Start date: September 1, 2020
Phase: N/A
Study type: Interventional

Summary: OBJECTIVE(S)/RESEARCH QUESTION(S) Does an orthosis combined with exercise therapy results in less pain and less conversion to surgery than an orthosis alone in patients with first carpometacarpal osteoarthritis (CMC-1 OA), at three months and one year after the start of treatment? HYPOTHESIS We hypothesize that the orthosis + exercise therapy group has less pain and conversion to surgery will be lower than the orthosis group. STUDY DESIGN Randomized controlled multicenter trial STUDY POPULATION(S)/DATASETS Patients with irst carpometacarpal osteoarthritis (CMC-1 OA) seeking treatment INTERVENTION Orthosis + exercise therapy USUAL CARE/COMPARISON Orthosis only OUTCOME MEASURES Primary outcomes: pain and conversion to surgery SAMPLE SIZE CALCULATION/DATA ANALYSIS Two groups of 80 participants; analysis based on repeated measures analysis (for pain) and chi-squared (for conversion to surgery). We initially planned to perform a logistic regression for conversion to surgery but decided prior to data analysis that we will be using Chi-square tests to determine whether there is a between-group difference in the proportion converting to surgery. We will use a repeated measures analysis for pain. COST-EFFECTIVENESS ANALYSIS (CEA)/ BUDGET IMPACT ANALYSIS (BIA) Economic evaluation will be done from societal & healthcare perspectives, according cost-effectiveness analysis (CEA) guidelines. Medical & non-medical costs and consequences (i.e. productivity loss) will be collected and taken into account. Both CEA and cost-utility analysis will be performed, using conversion to surgery and Quality-adjusted life years (QALYs), respectively TIME SCHEDULE Start preparation: December 2019, inclusion: October 2020- December 2022, final report: December 2023

NCT ID: NCT05626192 Recruiting - Clinical trials for Thumb Osteoarthritis

Anatomical Evaluation of the APL Tendons in Thumb CMC Joint and Osteoarthritis

Start date: November 13, 2022
Phase:
Study type: Observational

Certain ligaments in the human body are designed to be a static stabilizer and others to have a sensory function thus remains an unresolved issue. The presence of mechanoreceptors (sensory corpuscles and free nerve endins) in the human knee and ankle ligaments has implies a sensory role of ligaments in providing afferent information, which in turn regulates intrinsic stiffness in the muscles surrounding the joint, contribuiting to dynamic joint stability. The aim of this study is to use immunohistochemical methods to analyze the general innervation and possible existence of sensory corpuscles in the thumb carpometacarpal (CMC) joint. This study can help to know the contribution of the tendon insertions and ligaments in the dynamic thumb CMC joint stability.

NCT ID: NCT05499559 Recruiting - Hand Osteoarthritis Clinical Trials

Effects of 12-week Digital Treatment in Patients With Hand OA on Pain and Function

Start date: April 1, 2022
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to evaluate the effect of a 12 week digital treatment program for patients with hand osteoarthritis. The treatment consisted of exercises and educational sessions with respect to the disease, its natural course and recommended treatment strategies. Design: An observational longitudinal cohort study. The investigators will include participants who participated in the digital treatment of Joint Academy® for 3 months. Outcomes: Investigators will analyze pain with Numeric Rating Scale (NRS) 0-10 (best to worst), function with the Functional Index for Hand OsteoArthritis (FIHOA) and HRQL with EQ-5D-5L at baseline and at 3 months. Main outcome will be change in pain. The investigators will also analyze minimally clinical important changes (improved or not) and mean changes in EQ-5D-5L index score, pain and function.

NCT ID: NCT05315297 Active, not recruiting - Clinical trials for Thumb Osteoarthritis

Pulsed Electromagnetic Field (PEMF) Therapy in Thumb CMC Arthritis

Start date: June 20, 2023
Phase: N/A
Study type: Interventional

Long-Term Objective: Determine if high-frequency PEMF therapy reduces pain in patients with thumb carpometacarpal (CMC) joint osteoarthritis (OA). Study Design and Methods: This will be a randomized controlled pilot study with 60 subjects with CMC OA randomly divided in two groups. Thirty subjects will receive high-frequency PEMF therapy overlying the CMC joint overnight daily for four weeks. The other 30 subjects will receive a sham PEMF therapy device applied to the same joint overnight daily for four weeks. Pain and function questionnaires will be obtained for all patients at enrollment, four weeks, and six weeks.

NCT ID: NCT05307510 Recruiting - Clinical trials for Thumb Osteoarthritis

Influence of Custom Orthosis Post Carpometacarpal (CMC) Arthroplasty

Start date: April 21, 2022
Phase: N/A
Study type: Interventional

This study aims to compare post-surgical outcomes of individuals who receive either a custom orthosis or prefabricated splint after carpometacarpal arthroplasty.

NCT ID: NCT05127005 Recruiting - Clinical trials for Thumb Osteoarthritis

Efficacy of Trapeziectomy Versus Sham Surgery in the Treatment of Osteoarthritis at the Base of the Thumb

FINTASY
Start date: January 20, 2022
Phase: N/A
Study type: Interventional

A multi-center randomized placebo-controlled clinical trial which determines the efficacy of trapeziectomy in patients with persistent painful osteoarthritis at the base of the thumb. The primary outcome is patient reported evaluation of pain and function of the wrist and hand at 6 months after the randomization to treatment group.