Hemorrhage Clinical Trial
Official title:
Apixaban Discontinuation Prior to Major Surgery
The ADIOS study is a prospective, observational study will evaluate one hundred and thirty (130) patients with non-valvular atrial fibrillation who are currently receiving treatment with apixaban as indicated to reduce the risk of stroke or systemic embolism, and who require an elective major surgical or invasive procedure will be included in the study. The purpose of the study is to evaluate the efficacy of the recommended pre-procedure washout period of 48 hours.
This study will estimate for what proportion of patients a 48 hour pre-procedure apixaban
discontinuation is sufficient to achieve minimal apixaban plasma levels (less than 30 ng/mL)
prior to surgery. The investigators hypothesize that this portion will be 80-95%.
All patients will have a blood draw at 48 hours prior to procedure and then a second blood
draw on the morning of the procedure to test apixaban plasma and anti-Xa levels. Patients
will also receive a follow-up phone call at 30 days to collect information on clinical
events.
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