Thrombocytopenia Clinical Trial
Official title:
Thrombopoietin Levels Following Platelet Transfusion in Neonates With Thrombocytopenia
Infants who have low platelets and who require a platelet transfusion are included in this study. Platelet transfusions are routinely given to infants when their platelet count falls below a certain level. The study will look at the amount of platelets transfused. The purpose of the study is to evaluate the effect of platelet transfusions on the level of a protein (thrombopoietin) which is known to help control platelet production.
Thrombocytopenia, defined as a platelet count < 150,000/mm3, is a very common hematologic
problem in the neonatal period. Multiple etiologies are known to be associated with
thrombocytopenia in neonates. Thrombopoietin (TPO) is known to be the central regulator of
megakaryocyte and platelet production in adults and infants. However, the role of TPO in
neonatal platelet regulation is not well understood. TPO levels have been shown to be higher
in neonates with thrombocytopenia, with a decrease in TPO after resolution of the
thrombocytopenia. The response of TPO levels in neonates after platelet transfusion has
never been studied. In addition, the optimal volume of platelet transfusions has never been
studied in neonates. This study will evaluate the response to 2 different volumes of
platelet transfusion.
We hypothesize that a decrease in plasma TPO levels will be seen following a platelet
transfusion in a population of neonates with thrombocytopenia. We also hypothesize that a
platelet transfusion of 15 mL/kg will result in a greater rise in platelet count than a
transfusion pf 10 mL/kg of platelets.
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Time Perspective: Prospective
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