Thoracoabdominal Aortic Aneurysm Clinical Trial
Official title:
Investigation of the Cerebrospinal Fluid and Further Tissue Samples for Biomarker Indicating Spinal Ischemia and Organ Failure in Patients With Thoracoabdominal Aortic Aneurysm
Patients with a thoracoabdominal aortic aneurysm in need of an endovascular or open operative restructuring will be asked to participate in this study. After obtaining written consent a central venous catheter and a liquor drainage will be routinely placed during surgery. The catheter and the drainage will stay in the patients for at least 72 hours postoperatively. In total, nine measurements of the liquor and serum will be performed within a week in order to determine the following parameters: neuropeptide P, neuropeptide Y, neurofilament triplet protein (NFL), S100B, glial fibrillary protein (GFAp), lactate, glucose, or oxygen.
Patients with complex aortic diseases receiving an operative treatment are under risk of
spinal cord damage due to insufficient blood circulation of the spinal cord during surgery.
The risk depends on comorbidities, extent of surgery, and the perioperative management.
Despite an adequate preoperative imaging, assessment of the blood circulation of the spinal
cord during endovascular or open operative restructuring is struggling. Beside the
monitoring possibilities of the spinal cord functions during surgery, insufficient
approaches regarding early detection of spinal ischemia by using laboratory parameters
exist. Several biomarker, e.g. neuropeptide P, neuropeptide Y, neurofilament triplet protein
(NFL), S100B, glial fibrillary protein (GFAp), lactate, glucose, or oxygen, will be
evaluated singularly or as a bundle of markers in small patient groups. Surgeries of
thoracoabdominal aortic aneurysms are associated with high risks despite already existing
high standardized procedures (Cowan et al. 2003). The major complications are
cardiovascular, renal, pulmonary, gastrointestinal complications, and ischemias of the
spinal cord. Especially, the ischemia of the spinal cord is a feared complication caused by
the irreversibility and the small time frame.
During the study samples of liquor and tissues (serum, urine) will be drawn pre-, peri- and
postoperatively. Patients will receive a routinely placed liquor drainage due to the
temporal duration in surgery. The liquor drainage stays in the patient also in the early
postoperative phase. Hence, the patient will not be bothered with additional examinations.
Additionally, biomaterial (blood) will be drawn routinely and used for the biomarker
measurement as well as biobanking.
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