Thoracic Cancer Clinical Trial
Official title:
The Efficacy and Safety of Opioid-free Anesthesia(OFA) for Non-small-cell Lung Cancer Resection and Its Underlying Clinical Value: a Prospective Study
to investigate the efficacy and safety of opioid-free anesthesia for non-small-cell lung cancer resection and its underlying clinical value
Status | Recruiting |
Enrollment | 60 |
Est. completion date | December 1, 2025 |
Est. primary completion date | July 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - going through thoracoscopic lung surgery including lobectomy, segmentectomy, single or multiple wedge resection, and two of the above procedures combined; - able to complete the pain scoring face-to-face; - no cognitive dysfunction or history of anesthetic drug allergy; - ASA grade I-II Exclusion Criteria: -psychological disorders |
Country | Name | City | State |
---|---|---|---|
China | 180 Fenglin Road | Shanghai | |
China | Zhongshan Hospital | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Shanghai Zhongshan Hospital |
China,
Bello M, Oger S, Bedon-Carte S, Vielstadte C, Leo F, Zaouter C, Ouattara A. Effect of opioid-free anaesthesia on postoperative epidural ropivacaine requirement after thoracic surgery: A retrospective unmatched case-control study. Anaesth Crit Care Pain Med. 2019 Oct;38(5):499-505. doi: 10.1016/j.accpm.2019.01.013. Epub 2019 Feb 5. — View Citation
Devine G, Cheng M, Martinez G, Patvardhan C, Aresu G, Peryt A, Coonar AS, Roscoe A. Opioid-Free Anesthesia for Lung Cancer Resection: A Case-Control Study. J Cardiothorac Vasc Anesth. 2020 Nov;34(11):3036-3040. doi: 10.1053/j.jvca.2020.05.022. Epub 2020 May 27. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | acute postoperative pain scores | visual analog scale was used | day1 postoperation | |
Primary | acute postoperative pain scores | visual analog scale was used | day2 postoperation | |
Primary | occurrence of postoperative opioid-related adverse events | occurrence of postoperative opioid-related adverse events | day1 postoperation | |
Primary | occurrence of postoperative opioid-related adverse events | occurrence of postoperative opioid-related adverse events | day2 postoperation | |
Secondary | relapse free survival and overall survival | relapse free survival and overall survival | within 5 years | |
Secondary | occurrence of episodes of postoperative pain (VAS =4) | occurrence of episodes of postoperative pain (VAS =4) | within 48hours | |
Secondary | PCEA bolus consumption | PCEA bolus consumption | within 48hours | |
Secondary | need for rescue intravenous opioids or any type of painkiller | need for rescue intravenous opioids or any type of painkiller | within 48hours | |
Secondary | hospital length of stay and total hospital expenses | hospital length of stay and total hospital expenses | within 10days | |
Secondary | Pathologic results and TNM rating | Pathologic results and TNM rating | within one month |
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