Thoracic Aortic Aneurysms Clinical Trial
Official title:
BIOMECHANICAL AND MICROSTRUCTURAL PROPERTIES OF THE AORTIC WALL: A Pilot Study in Patients Undergoing Surgery for Ascending Aortic Aneurysms
NCT number | NCT03142074 |
Other study ID # | S59521 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | January 2017 |
Est. completion date | December 2023 |
An aortic aneurysm (thoracic or abdominal) is a permanent dilatation of the aorta caused by weakening in the arterial wall. The feared complication is aortic rupture or dissection, leading to potentially lethal aortic bleeding and associated with mortality rates up to 95%. The current diagnosis criteria do not suffice, therefore the goal of this study is the development of an improved biomechanics-based and microstructural-based diagnostic tool.
Status | Recruiting |
Enrollment | 180 |
Est. completion date | December 2023 |
Est. primary completion date | December 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients suffering from thoracic aortic aneurysms (ATAA), asymptomatic or symptomatic. - Patients with ruptured ATAA undergoing an emergency surgery. - Signed informed consent. Exclusion Criteria: - Patients with ruptured ATAA due to trauma. - The presence of any aneurysm feature that will prevent the collection of tissue samples suitable for the biomechanical and microstructural studies. |
Country | Name | City | State |
---|---|---|---|
Belgium | UZ Leuven | Leuven | Vlaams Brabant |
Lead Sponsor | Collaborator |
---|---|
Universitaire Ziekenhuizen KU Leuven |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Data collection of patients suffering from thoracic aortic aneurysms | General information (age, gender, height, weight, BMI); medicinal usage (beta-blockers, ACE inhibitors, statins, angiotensin receptor blockers, ...); cardiovascular risk factors (smoking, hypertension, dyslipidemia, diabetes, atrial fibrillation); cardiovascular properties (tricuspid aortic valve, inherited aortopathies, abdominal aortic aneurysm, prior open heart surgery, ...) | 6 years | |
Secondary | Investigation of correlation between rupture risk and mechanical and microstructural parameters | Mechanical properties (linear and non-linear stiffness) and histological properties (elastin fraction, collagen fraction, inflammation status, wall thickness) | 6 years |
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