Thoracic Aortic Aneurysm Clinical Trial
Official title:
Effective Treatments for Thoracic Aortic Aneurysms (ETTAA Study): A Prospective Cohort Study
This is a prospective observational cohort study that will collect data from the point of
referral through to secondary care, aiming for 3 years median follow-up (range 1-5 years).
The data collected will allow estimation of the success of any intervention (in terms of
reducing rate of aneurysm growth, rupture or dissection) as well as estimation of the risks
associated with the three procedures. Clinical outcomes in the three treatment groups will
be described.
Aims
We aim to answer the following questions:
1. Without procedural intervention for chronic thoracic aortic aneurysm (CTAA), what is
the risk of aneurysm growth, dissection, rupture, permanent neurological injury or
death? What is the effect on quality of life (QoL)?
2. If a patient has endovascular stent grafting (ESG) or open surgical repair (OSR), what
is the risk of growth, dissection, rupture, permanent neurological injury or death?
3. How does QoL change from pre- to post intervention?
4. Can aneurysm or patient related predictors of good/poor treatment outcomes be
determined?
5. What is the most cost-effective strategy in:
1. Patients eligible for either ESG or OSR?
2. Patients eligible for either ESG or best medical therapy (BMT)?
3. Patients eligible for either watchful waiting (WW) or intervention (ESG/ OSR)?
6. What further research is required? What would be the most important research to pursue?
n/a
Observational Model: Cohort, Time Perspective: Prospective
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