Clinical Trials Logo

Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT01390181
Other study ID # HUM00048364
Secondary ID
Status Recruiting
Phase N/A
First received June 30, 2011
Last updated January 3, 2013
Start date September 2011

Study information

Verified date January 2013
Source University of Michigan
Contact Nickole L Carlson, BSN
Phone 734 232 4780
Email ngarvey@med.umich.edu
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Interventional

Clinical Trial Summary

The specific aims of this study are to:

- Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in individuals with bicuspid aortic valve and ascending aortic or aortic sinus measurements >40mm.

- Assess the effect on MMP levels during treatment with losartan, an angiotensin II receptor blocking agent.

- In the setting of losartan therapy for one year, evaluate the response of MMP levels in these patients, and clinical outcomes including effects on aortic growth rate


Recruitment information / eligibility

Status Recruiting
Enrollment 25
Est. completion date
Est. primary completion date December 2013
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- Adults >age 18 years and < 65 years old

- Able to give informed consent

- Presence of a bicuspid aortic valve (functional or true bicommisural)and ascending aorta or sinus of Valsalva >4.0cm

- No contraindications to treatment with Losartan, an Angiotensin II receptor blocker

- Able to safely participate in a 4 week drug washout period if currently taking an angiotensin II receptor blocker or ACE inhibitor.

Exclusion Criteria:

- Unable to safely take losartan due to one or more of the following:

- Hypersensitivity to losartan or other angiotensin receptor blockers

- Pregnancy

- Nursing mothers

- History of angioedema

- Hypotension - chronically volume depleted patients

- Hepatic or renal impairment (Cr>1.5mg/dL)

- Hyperkalemia (K+>4.8)

- Renal artery stenosis

- Severe congestive heart failure (class III-IV)

- Currently taking potassium supplements or salt substitutes containing potassium

- Currently taking lithium

- Prior surgical intervention to aorta or aortic valve

- Unable or unwilling to give informed consent and follow up with study activities

- Currently taking an angiotensin receptor blocker or ACE inhibitor specifically for hypertension and are therefore unable to or are unwilling to participate in a 4 week drug washout period.

- Females of child bearing who are unwilling to practice adequate birth control throughout the study.

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Intervention

Drug:
Cozaar
Angiotensin II Receptor Blocker

Locations

Country Name City State
United States University of Michigan Ann Arbor Michigan

Sponsors (1)

Lead Sponsor Collaborator
University of Michigan

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Inflammatory markers level Record changes in levels of MMP-2, MMP-9, TIMP 1, TIMP 2, & TGFB in circulation while taking medication from baseline at 3 months, 6 months and 12 months. Baseline and 12 months No
See also
  Status Clinical Trial Phase
Recruiting NCT00339053 - Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Phase 4
Not yet recruiting NCT05395598 - Incidence of Major Complication in Case of Thoracic Aortic Aneurysm
Recruiting NCT00549315 - Clinical Study of Thoracic Aortic Aneurysm Exclusion N/A
Recruiting NCT05777460 - Mid- and Long-term Outcomes of Custom-made Aortic Devices
Active, not recruiting NCT05146375 - Genes Modulating the Severity of Aortic Aneurysms (MSF1-TGFBR2)
Completed NCT01082172 - South American Thoracic Stent-Graft Study N/A
Recruiting NCT03824626 - Biomechanical Reappraisal of Planning for Thoracic Endovascular Aortic Repair
Completed NCT04663074 - Intravascular Ultrasound (IVUS) in Complex Aortic Endovascular Interventions
Recruiting NCT04747626 - B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair N/A
Active, not recruiting NCT05143138 - Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used as a Bridging Stent With Branched and Fenestrated Endografts in the Treatment of Aortic Aneurysms Involving the Renal-Mesenteric Arteries
Completed NCT00111176 - STARZ-TX2 Clinical Study: Study of Thoracic Aortic Aneurysm Repair With the Zenith TX2 Endovascular Graft N/A
Recruiting NCT05639400 - Thoraflex Hybrid and Relay Extension Post-Approval Study
Terminated NCT02735720 - The CardiOvascular Remodeling Following Endovascular Aortic Repair (CORE) Study
Completed NCT02256163 - Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm N/A
Recruiting NCT06377033 - Using the EHR to Advance Genomic Medicine Across a Diverse Health System N/A
Recruiting NCT06094127 - Zenith Thoracic Alpha (ZTA) Post-Market Data Collection
Recruiting NCT03998631 - Comparison of Carbon Dioxide and Saline Flush to Saline Flush in TEVAR and TAVI Procedures to Reduce Cerebral Ischemia Phase 1
Completed NCT05414318 - CTAG Dissection/Trauma Post Marketing Surveillance Japan
Completed NCT04756778 - Indexed Aortic Area in Bicuspid Aortic Valve Aortopathy
Withdrawn NCT04197648 - Effects of Exercise on Thoracic Aneurysms N/A