Thoracic Aortic Aneurysm Clinical Trial
Official title:
The Effect of Losartan Treatment on Matrix Metalloproteinase Levels and Outcomes in Bicuspid Aortic Valve Patients
NCT number | NCT01390181 |
Other study ID # | HUM00048364 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | June 30, 2011 |
Last updated | January 3, 2013 |
Start date | September 2011 |
The specific aims of this study are to:
- Establish baseline levels of circulating MMP-2 and -9 , TIMP-1and- 2 and TGFB levels in
individuals with bicuspid aortic valve and ascending aortic or aortic sinus
measurements >40mm.
- Assess the effect on MMP levels during treatment with losartan, an angiotensin II
receptor blocking agent.
- In the setting of losartan therapy for one year, evaluate the response of MMP levels in
these patients, and clinical outcomes including effects on aortic growth rate
Status | Recruiting |
Enrollment | 25 |
Est. completion date | |
Est. primary completion date | December 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Adults >age 18 years and < 65 years old - Able to give informed consent - Presence of a bicuspid aortic valve (functional or true bicommisural)and ascending aorta or sinus of Valsalva >4.0cm - No contraindications to treatment with Losartan, an Angiotensin II receptor blocker - Able to safely participate in a 4 week drug washout period if currently taking an angiotensin II receptor blocker or ACE inhibitor. Exclusion Criteria: - Unable to safely take losartan due to one or more of the following: - Hypersensitivity to losartan or other angiotensin receptor blockers - Pregnancy - Nursing mothers - History of angioedema - Hypotension - chronically volume depleted patients - Hepatic or renal impairment (Cr>1.5mg/dL) - Hyperkalemia (K+>4.8) - Renal artery stenosis - Severe congestive heart failure (class III-IV) - Currently taking potassium supplements or salt substitutes containing potassium - Currently taking lithium - Prior surgical intervention to aorta or aortic valve - Unable or unwilling to give informed consent and follow up with study activities - Currently taking an angiotensin receptor blocker or ACE inhibitor specifically for hypertension and are therefore unable to or are unwilling to participate in a 4 week drug washout period. - Females of child bearing who are unwilling to practice adequate birth control throughout the study. |
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | University of Michigan | Ann Arbor | Michigan |
Lead Sponsor | Collaborator |
---|---|
University of Michigan |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Inflammatory markers level | Record changes in levels of MMP-2, MMP-9, TIMP 1, TIMP 2, & TGFB in circulation while taking medication from baseline at 3 months, 6 months and 12 months. | Baseline and 12 months | No |
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