Thinness Clinical Trial
Official title:
Genome Study in Constitutional Thinness
Constitutional thinness (CT) is a recently defined entity as a differential diagnosis of
anorexia nervosa (AN), considered to be the most frequent cause of low body mass index (BMI)
in young women. CT subjects present no AN psychiatric traits, preserved menses, no biological
signs of undernutrition and balanced energy metabolism despite a Body Mass Index (BMI) <17 kg
/ m².
CT familial aggregation, low body mass without a hormonal explanation, and specific appetite
regulation profile suggest a specific genetic profile in these subjects.
Objective: A family linkage study in order to identify genes involved in the constitutional
thinness phenotype by using genome wide scan (GWAS) techniques Studied population: Fifty
families including at least one well phenotyped CT index case (grade 2 or 3 of thinness
according WHO classification). Blood or saliva is sampled for DNA extraction.
Perspectives: Revealing eventual abnormalities could lead to a more precise diagnosis of
constitutional thinness and new hypothesis in understanding extreme bodyweight mechanisms.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02320110 -
Correlation of Irisin and Adipokine Levels With Body Mass Index and Risk Factors for Metabolic Syndrome in Hispanic Children
|
N/A | |
| Completed |
NCT02476578 -
Low Indexes of Metabolism - Information to Teams (LIMIT)
|
N/A | |
| Completed |
NCT00072917 -
The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women
|
N/A | |
| Completed |
NCT04135729 -
Mental Health in Fitness Instructors
|
||
| Completed |
NCT02791100 -
Promotion of Egg and Eggshell Powder Consumption Improve Nutritional Status of Children in Halaba Ethiopia
|
N/A | |
| Completed |
NCT03346473 -
The Double Burden of Malnutrition Among Adolescents in Low-income and Middle-income Countries
|
N/A | |
| Recruiting |
NCT02682537 -
IC-BASAROTs: New Practice Method for More Accurate Bed-side Assessment of Individual Energy Expenditure
|
||
| Recruiting |
NCT03221322 -
How do Super Lean Subjects Keep Resistant to Body Weight Gain?
|
||
| Recruiting |
NCT05791305 -
Double Duty Interventions and Its Impact on Double Burden of Malnutrition in Children Under Five Years
|
N/A | |
| Recruiting |
NCT05804929 -
Phenotypic Characteristics of Superlean Individuals Including Gut Microbiome
|