Thin Endometrium Clinical Trial
— PRP(a-PRP)Official title:
Effect of Autologous Platelet Rich Plasma(a-PRP) Intrauterine Instillation in Infertile Women With Thin Endometrium in Frozen-thawed Embryo Transfer Cycle: a Randomized Controlled Study
This study sought to compare the endometrial thickness among infertile women with a history of thin endometrium together with previous cancellation from IVF/ICSI inspection of intrauterine instillation of autologous-PRP or no treatment before embryo transfer in the frozen-thaw cycles.
Status | Recruiting |
Enrollment | 36 |
Est. completion date | May 31, 2025 |
Est. primary completion date | January 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients who will undergo frozen embryo transfer (Frozen-thawed cycle) - Age above 18 years - Thai nationality - Have a history of cycle cancellation due to a thin endometrium <7 mm. after standard hormonal treatmetn Exclusion Criteria: - medical conditions eg. Platelet dysfunction , vWD - thrombocytopenia <100,000 cell/mm3 - Receive antiplatelet therapy - Uterine anomaly, cavity distortion eg submucous myoma uteri, uterine synergia, endometrial polyp |
Country | Name | City | State |
---|---|---|---|
Thailand | Siriraj Hospital | Bangkok Noi | Bangkok |
Lead Sponsor | Collaborator |
---|---|
Mahidol University |
Thailand,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | endometrial thickness | compare endometrial thickness among 3 group | day 12 | |
Secondary | endometrial thickness difference between day 8 and day 12 | compare endometrial thickness day 8 and day 12 | between day 8 and day 12 | |
Secondary | clinical pregnancy rate | seen FHB at 12 weeks | 12 weeks | |
Secondary | chemical pregnancy rate | hcg > 25 u | 2 weeks after transfer | |
Secondary | miscarriage rate | abortion < 12 weeks | up to 12 weeks | |
Secondary | cancellation rate | cancel cycle from thin endometrium < 7 mm | day 14 |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03724617 -
Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium
|
N/A | |
Not yet recruiting |
NCT04100655 -
The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium
|
N/A | |
Recruiting |
NCT04292886 -
Thin Endometrium Undergoing Frozen-thawed Embryo Transfer
|
N/A | |
Completed |
NCT05455151 -
Hysteroscopic Injections of Autologous Endometrial Cells and Platelet-rich Plasma in Patients With Thin Endometrium
|
Phase 1 | |
Recruiting |
NCT06379659 -
Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer
|
Phase 1/Phase 2 | |
Recruiting |
NCT03067623 -
Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness
|
Phase 2 |