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Clinical Trial Summary

The investigation is devoted to the study of the effect of the introduction of autologous platelet-rich plasma (PRP) on the thickness of the endometrium. It was found that the injection of PRP and endometrial cells resuspended in PRP into the endometrium of patients with thin endometrium leads to an increase in the proliferation of endometrial cells, and as a result, to an increase in its thickness.


Clinical Trial Description

The study enrolled 115 patients with thin endometrium (<7 mm at implantation window) and infertility. The cohort was divided into groups based on the treatment regimen. Group 1 (the control, n=30) underwent conservative therapy. Group 2 (n=42) received intraendometrial injections of autologous PRP instead of the conservative therapy. Group 3 (n=38) received identical injections after conservative therapy. Group 4 (n=5) received injections of the minimally manipulated autologous endometrial cells suspended in autologous PRP. Injections of PRP and endometrial cells suspended in autologous PRP into basal layer of endometrium facilitate the reconstitution by enhancing cell proliferation and angiogenesis. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05455151
Study type Interventional
Source Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Contact
Status Completed
Phase Phase 1
Start date October 1, 2018
Completion date March 1, 2021

See also
  Status Clinical Trial Phase
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Not yet recruiting NCT04100655 - The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium N/A
Recruiting NCT04292886 - Thin Endometrium Undergoing Frozen-thawed Embryo Transfer N/A
Recruiting NCT06379659 - Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer Phase 1/Phase 2
Recruiting NCT06234540 - a-PRP Intrauterine Instillation in Women With Thin Endometrium N/A
Recruiting NCT03067623 - Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness Phase 2