Thin Endometrium Undergoing Frozen-thawed Embryo Transfer

Thin Endometrium Clinical Trial

Official title:
Hormone Replacement Versus Tamoxifen Combined Of Hormone Replacement in Women With a Thin Endometrium Undergoing Frozen-thawed Embryo Transfer

Status Recruiting

Clinical Trial Summary

The endometrium is essential for embryo implantation. The clinical pregnancy rate and live birth rate of patients with thin endometrium are significantly lower than those of normal endometrium. Previous studies have shown that tamoxifen has advantages for improving endometrial thickness. However, there is still a lack of evidence from randomized clinical trials comparing the efficacy between hormone replacement and Tamoxifen combined Of hormone replacement.This is a prospective, randomized placebo-controlled, double-blind clinical trial that includes 120 patients younger than 38 years old with a thin endometrium preparing for frozen embryo transfer. Participants will be randomly assigned (1: 1) into two parallel groups: estrogen replacement and tamoxifen combined with estrogen replacement.Frozen embryo resuscitation transfer cycle for thin endometrium patients。This is the first randomized controlled trial to comparing estrogen and estrogen combined with tamoxifen for endometrial improvement，The results of this study will provide evidence for the efficacy of the strategy of frozen embryo transfer cycle for thin endometrium patients.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Thin Endometrium

Clinical Trial Details

NCT number	NCT04292886
Study type	Interventional
Source	Nanjing University
Contact	Qingqing Shi, Ph.D
Phone	15996312878
Email	qqshnju@sina.com
Status	Recruiting
Phase	N/A
Start date	October 1, 2019
Completion date	November 30, 2021

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See also
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Completed	`NCT03724617` - Clinical Study of Umbilical Cord Mesenchymal Stem Cells Combined With Collagen Scaffold in the Treatment of Thin Endometrium	N/A
Not yet recruiting	`NCT04100655` - The Effect of the GM-CSF Gel on the Endometrial Thickness in Infertile Women With Thin Endometrium	N/A
Completed	`NCT05455151` - Hysteroscopic Injections of Autologous Endometrial Cells and Platelet-rich Plasma in Patients With Thin Endometrium	Phase 1
Recruiting	`NCT06379659` - Effectiveness of Intrauterine Growth Hormone Administration as an add-on Therapy to Conventional Hormone Therapy Compared to Placebo in Patients With Thin Endometrium Undergoing Frozen Thawed Embryo Transfer	Phase 1/Phase 2
Recruiting	`NCT06234540` - a-PRP Intrauterine Instillation in Women With Thin Endometrium	N/A
Recruiting	`NCT03067623` - Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness	Phase 2