the Incidence of Ventilator Associated Pneumonia (VAP) Clinical Trial
Official title:
The Effect of Intensive Insulin Therapy on the Incidence of Ventilator-Associated Pneumonia in Surgical Critically Ill Patients
Aim. To determine whether the maintenance of normoglycemia decreases the incidence of
ventilator associated pneumonia (VAP), reduces its treatment period and the length of stay
in the intensive care unit.
Methods. Prospective, randomized, controlled trial. We enrolled 117 mechanically ventilated
trauma (71) and abdominal (46) surgical patients, older than 18, of both sex. In 57 patients
(strict glucose control group) we aimed to maintain the blood glucose level between 4.4 and
6. 1 mmol/L, while in 60 patients (standard glucose control group) it was maintained between
7.8 and 10.0 mmol/L, with the use of continues insulin infusion. Insulin dose adjustments
were based on measurements of glucose in capillary blood sample.
Key words: surgical patients; mechanical ventilation; pneumonia; blood glucose; insulin
infusion; hospital stay
see brief summary ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Prevention