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Combined Chelation Therapy in Patients With Transfusion Dependent Thalassemia and Iron Overload

Thalassemia Clinical Trial

Official title:
Safety of Deferasirox (ICL670) and Deferoxamine (Desferal or DFO) Combined Chelation Therapy in Patients With Transfusion Dependent Thalassemia and Iron Overload

Clinical Trial Summary

This is a pilot study looking at the safety and efficacy of giving combination chelation with deferasirox and deferoxamine. The hypothesis is that combination chelation is safe in decreasing overall iron in patients with thalassemia.

Clinical Trial Description

This was a phase two pilot clinical trial designed to evaluate the safety and efficacy of the combination of deferasirox and deferoxamine in transfusion dependent thalassemia with a range of systemic iron burden. The duration of combined therapy was 12 months. Changes in liver iron concentration, ferritin, myocardial iron, and serum creatinine was monitored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00901199
Study type Interventional
Source UCSF Benioff Children's Hospital Oakland
Contact
Status Completed
Phase Phase 2
Start date September 2007
Completion date October 2012
View Details
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