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The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major

Thalassemia Major Clinical Trial

Official title:
The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major

Clinical Trial Summary

The effect of N-acetylcysteine as antioxidant and its effect on pretransfusion hemoglobin and iron overload in patients with thalassemia were compared to patients who didn't receive n-acetylcysteine after 3 months of study duration

Clinical Trial Description

N-acetylcysteine( NAC) is a widely used mucolytic drug and several studies had reported its efficacy as anti oxidant. Patients with thalassemia major are at great risk for oxidative stress due to excess of b-globin chains and iron overload. In this study the investigators compared the effect of NAC on oxidative status , pretransfusion hemoglobin levels and iron overload in thalassemia patients before and after treatment with NAC for 3 months and with that of patients who served as controls. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04260516
Study type Interventional
Source Beni-Suef University
Contact
Status Completed
Phase Phase 1
Start date June 3, 2019
Completion date December 30, 2019
View Details
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