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Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major — AnloThal  

Thalassemia Major Clinical Trial

Official title:
Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major

Clinical Trial Summary

This study aims to investigate the use of amlodipine, a drug that blocks the uptake of calcium into cells, in the prevention and treatment of iron overload in patients with thalassemia major. Since iron uses the same calcium channels to enter the heart, pancreas and other organs, blocking these channels might help to prevent the accumulation of iron in these tissues. The study will follow 10 patients with thalassemia major: 5 will openly receive amlodipine and 5 will serve as controls, not receiving any additional drugs. Patients will be monitored through one year with an additional year of follow up after the group using amlodipine stops its use. Monitoring will occur through the measurement of blood ferritin as well as live and heart T2* by MRI.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01125254
Study type Interventional
Source University of Campinas, Brazil
Contact
Status Completed
Phase Phase 2/Phase 3
Start date September 2008
Completion date July 2011
View Details
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