Clinical Trials Logo
  1. Home
  2. Thalassemia Major
  3. NCT00480506

Monitoring of Erythroid Lineage Specific Chimerism Following Allogeneic Hematopoietic Transplantation for Thalassemia Major

Thalassemia Major Clinical Trial

Official title:
Monitoring of Erythroid Lineage Specific Chimerism Following Allogeneic Hematopoietic Transplantation for Thalassemia Major

Clinical Trial Summary

The purpose of this study is to collect peripheral blood and bone marrow aspirate samples from thalassemia patients in Tehran, in a collaborative effort to develop an erythroid lineage specific chimerism assay applicable to patients with thalassemia. Development of such an assay would be useful both for identification of the exact mutation causing the disease, as well as for providing a direct method to measure and monitor the kinetics of donor erythropoiesis in this patient population following transplant.

Clinical Trial Description

- In the first phase of the study we will develop a panel of reagents designed to identify predominant thalassemia mutations in the Iranian population, as well as alternative highly variable erythroid specific polymorphisms. To determine how informative this panel is, these reagents will be applied to samples collected from patients homozygous for the disorder, and compared to patients with thalassemia trait and normal Iranian donors.

- In the second phase, we propose to serially measure and compare erythroid lineage chimerism with overall genomic chimerism following transplant. Samples will be collected from participants before and at 1, 2, 3, 6 and 12 months following transplant and cryopreserved. Peripheral blood from the stem cell donor will also be collected and cryopreserved. Participants will undergo myeloablative or nonmyeloablative transplant. ;

Study Design

Time Perspective: Retrospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00480506
Study type Observational
Source Dana-Farber Cancer Institute
Contact
Status Completed
Phase N/A
Start date April 2004
Completion date October 2005
View Details
See also
  Status Clinical Trial Phase
Completed NCT02559648 - Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis Phase 2
Recruiting NCT02126046 - Unrelated Umbilical Cord Blood Following HLA-haploidentical Hematopoietic Stem Cell Transplantation in Patients With β-thalassemia Major N/A
Completed NCT01125254 - Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major Phase 2/Phase 3
Terminated NCT00034528 - Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or Thalassemia Phase 2
Completed NCT00733811 - Efficacy Study of the Use of Sequential DFP-DFO Versus DFP Phase 4
Enrolling by invitation NCT02986698 - In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM) Phase 1
Not yet recruiting NCT06026839 - Longitudinal Study on the QoL of Pediatric Patients After HSCT and Its Influencing Factors
Terminated NCT00007072 - Phase II Study of Azacitidine and Phenylbutyrate in Patients With Thalassemia Major Phase 2
Completed NCT04292314 - Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia Phase 2/Phase 3
Completed NCT02049450 - Study of Efficacy and Safety of INC424 in Regularly Transfused Patients With Thalassemia. Phase 2
Active, not recruiting NCT04523376 - Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies N/A
Completed NCT03992001 - Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients Phase 4
Not yet recruiting NCT05777733 - NAC Effect on Iron Overload and Blood Transfusion in β-thalassemia Major Phase 1
Completed NCT01241357 - High-Tc Susceptometer to Monitor Transfusional Iron Overload Phase 2
Completed NCT00749515 - Pilot Study for Patients With Poor Response to Deferasirox Phase 4
Completed NCT04260516 - The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major Phase 1
Recruiting NCT02307786 - Long Term Outcomes in β Thalassemia Major N/A
Not yet recruiting NCT01323608 - The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study Phase 4
Completed NCT00005893 - Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders N/A
Recruiting NCT06137079 - "Iron Overload and Endocrinological Diseases"