Neutropenia Clinical Trial
OBJECTIVES: I. Determine the efficacy of bone marrow transplantation using matched related
donors in patients with nonmalignant hematologic disorders.
II. Determine the quality of life, absence of adverse effects (e.g., graft versus host
disease and B cell lymphoproliferative disease), and completeness of recovery of their
underlying condition in these patients with this treatment regimen.
PROTOCOL OUTLINE: Patients receive IV or oral busulfan every 6 hours on days -9 to -6;
cyclophosphamide IV on days -5 to -2; anti-thymocyte globulin IV on days -4 to -2; and
allogeneic bone marrow transplantation (BMT) on day 0.
Patients with class 3 thalassemia (liver edge greater than 2 cm below costal margin, a
history of inconsistent chelation, and portal fibrosis) receive a less intensive
conditioning regimen consisting of oral busulfan every 6 hours on days -7 to -4;
anti-thymocyte globulin IV on days -5 to -1 and days 1-5; cyclophosphamide IV on days -3 to
-2; and allogeneic BMT on day 0.
Patients are followed at day 28, and then at 3, 6, 12, and 24 months.
;
Primary Purpose: Treatment
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