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Analysis of RV-Dysfunction in Fallot Patients — Fallot  

Tetralogy of Fallot Clinical Trial

Official title:
Tissue Doppler Imaging - A Promising Technique To Assess Myocardial Function In Adult Fallot Patients

Clinical Trial Summary

In the presented study TDI will be used as a modern technique to characterize RV-function in Fallot patients at rest and during different exercise conditions.

Clinical Trial Description

Tissue Doppler imaging (TDI) presents a modern technique to depict the velocity of tissue motion within a distinct area of the myocardium providing amendatory characterization of diastolic and systolic function of the heart. TDI is hypothesized to be of additional value in the evaluation of adult congenital heart disease, especially tetralogy of Fallot (TOF), which is one of the most common conditions. In particular, Fallot patients are at risk of developing right ventricular (RV) dysfunction due to pulmonary valve defects or alterations of the outflow tract. It is pivotal to recognize this progression at an early stage before irreversible changes occur. Aim of the study is to test feasibility of TDI in Fallot patients as a new technique that provides new parameters to characterize RV dysfunction, more precise than common methods. Additionally TDI is performed at rest and during different endurance testings (passive Leg Raising (PLR), handgrip (HG) and cardiopulmonary exercise (CPX), as certain changes might be compensated at rest, first apparent during exercise. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03835494
Study type Interventional
Source Heinrich-Heine University, Duesseldorf
Contact
Status Completed
Phase N/A
Start date November 1, 2018
Completion date February 28, 2019
View Details
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