Testicular Cancer Clinical Trial
Official title:
Identification of Predictive Markers for Testis Cancer in a Population of Men With High Risk
Testis cancer with germ cells is the most frequent cancer of young men and its incidence is
in constant increase in many industrialized countries, as in France. An increased risk of
developing testis cancer has been described in patients with testicular ectopia history and
testicular cancer history (controlateral testicular cancer) and more recently suggested in a
population of hypofertile men with altered spermatogenesis. To a better understanding of
this risk, an attempt of characterization of this group of patients has been proposed in the
present work.
The general objective of this project is to characterize morphological and molecular markers
of hypofertility which could serve as predictive markers of testis malignant transformation.
In this project conducted in 3 establishments, the investigators propose:
- To select a population of hypofertile patients exhibiting compatible clinical and
morphological characters with a high risk of testis tumoral transformation (secretory
azoospermia and/or a history of testicular ectopia. To determine the spermatogenic
arrests on histological criteria (score of Jonhsen).
- To study the expression of four proteins or family of proteins suspected of being
involved in testis tumorogenesis such as: the Placenta Alkaline Phosphatase (PLAPE),
cyclin A1, VASA and connexin (Cx) by immunohistochemistry and by real-time quantitative
RT-PCR analysis real-time analyses.
- To establish a possible correlation between the clinical data, spermatogenesis arrest
and the expression of these biomarkers.
These approaches would allow to identify, in this population of hypofertile patients,
subgroups of men who could develop tumours with germ cells, and subsequently to propose
potential biomarkers for testis cancer. A more clinical observation of these subgroups will
be also proposed.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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