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Temporal Lobe Epilepsy clinical trials

View clinical trials related to Temporal Lobe Epilepsy.

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NCT ID: NCT06466681 Recruiting - Clinical trials for Temporal Lobe Epilepsy

Changes in Attentional Control After a Focal Seizure.

ATTENTIONEPIF
Start date: March 4, 2024
Phase:
Study type: Observational

Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.

NCT ID: NCT06269822 Completed - Clinical trials for Temporal Lobe Epilepsy

Autonomic Dysfunction in Temporal Lobe Epilepsy and SUDEP

Start date: September 1, 2022
Phase:
Study type: Observational

The study aimed at detection of autonomic dysfunction among cases with temporal lobe epilepsy; using different electrophysiological techniques. Moreover, it aimed at finding any correlation between electrophysiological tests and SUDEP risk.

NCT ID: NCT05794295 Not yet recruiting - Clinical trials for Temporal Lobe Epilepsy

Sleep Architecture & Intrinsic Oscillatory and Network Connectivity in Cognition and Executive Dysfunction in TLE

Start date: July 2024
Phase: N/A
Study type: Interventional

Temporal Lobe Epilepsy (TLE) patients and healthy controls will undergo a night of sleep at the UC Davis Epilepsy Monitoring Unit (EMU) to characterize sleep architecture. A subset of TLE patients will be randomly assigned to an Acoustic Stimulation (AS) or SHAM stimulation night and return at least 7 days later for the other condition. Cognitive tests will be conducted 90 minutes prior to sleep (learning and immediate recall) and again 1 hour after awakening for 120 minutes (delayed recall and attention), while monitoring neural networks using functional Magnetic Resonance Imaging (fMRI).

NCT ID: NCT05609084 Recruiting - Epilepsy Clinical Trials

Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy

REPREO
Start date: March 30, 2023
Phase: N/A
Study type: Interventional

Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this procedure presents a high risk of increasing cognitive difficulties and may even be contraindicated for this reason alone. The difficulties found are impairments in lexical access (anomia) and verbal memory and affect more than 60% of patients . Preoperative cognitive rehabilitation could influence brain plasticity mechanisms but there are currently no recommendations on this topic. In this context, the investigators have developed a speech rehabilitation procedure specific to the needs of ELTPR patients. They rely on cognitive hypotheses explaining the disorders but also on models of rehabilitation-induced neural plasticity likely to improve cognitive reserve before surgery. The investigators hypothesize that preoperative cognitive language rehabilitation in ELTPR patients may decrease surgical risk and improve postoperative language prognosis. The primary objective is to demonstrate the protective efficacy of preoperative speech rehabilitation on language performance postoperatively.

NCT ID: NCT05179083 Recruiting - Clinical trials for Temporal Lobe Epilepsy

Exercise for Brain Regeneration in Epilepsy

Start date: August 20, 2022
Phase: Phase 1
Study type: Interventional

Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions. Given this significant burden, effective treatments to prevent dementia and new disease modifying therapies are urgently needed. Regeneration of lost neurons with new ones (i.e., neurogenesis) is compromised at early stages of dementia and in part correlates with cognitive impairment in Alzheimer's disease. Boosting the neurogenesis delays the cognitive impairment in animal models of dementia and has been proven beneficial in improving the memory in rodent studies. Aerobic exercise is the most potent known stimulator of neurogenesis in animal models. A crucial next step is to translate endogenous regenerative strategies to people. The purpose of this study is to demonstrate the feasibility and investigate the effects of an exercise program on neurogenesis and cognitive improvement in epilepsy patients.

NCT ID: NCT05159609 Completed - Clinical trials for Temporal Lobe Epilepsy

Closed Loop Auditory Stimulus in Sleep and epilepsY

CLASSY
Start date: October 1, 2020
Phase: N/A
Study type: Interventional

This is a single-centre pilot study of a non-invasive auditory stimulation during sleep in participants with temporal lobe epilepsy.

NCT ID: NCT05019404 Recruiting - Clinical trials for Minimally Invasive Surgery

Minimally Invasive Surgical Epilepsy Trial for Temporal Lobe Epilepsy

MISET-TLE
Start date: April 25, 2023
Phase: N/A
Study type: Interventional

Temporal lobe epilepsy (TLE) is a chronically neurological disease characterized by progressive seizures. TLE is the most frequent subtype of refractory focal epilepsy in adults. Epilepsy surgery has proven to be very efficient in TLE and superior to medical therapy in two randomized controlled trials. According to the previous experience, the investigators use functional anterior temporal lobectomy (FATL) via minicraniotomy for TLE. To date, this minimally invasive open surgery has been not reported. The investigators here present a protocol of a prospective trail which for the first time evaluates the outcomes of this new surgical therapy for TLE.

NCT ID: NCT03643471 Recruiting - Clinical trials for Temporal Lobe Epilepsy

Advanced Magnetic Resonance Imaging in Temporal Lobe Epilepsy

Start date: January 2019
Phase:
Study type: Observational

We aim to o evaluate the role of conventional and advanced MRI sequences in diagnosis of idiopathic temporal lobe epilepsy including identification and lateralization of epileptogenic focus.

NCT ID: NCT02946151 Completed - Clinical trials for Temporal Lobe Epilepsy

Subcutaneous EEG in Epilepsy

Start date: November 2016
Phase: N/A
Study type: Interventional

The study is a two-phase study, which aims to explore the uses of a novel electrode type in detecting epileptic seizures. The electrode is designed for subcutaneous implantation with long-term monitoring in mind.

NCT ID: NCT02844465 Completed - Clinical trials for Temporal Lobe Epilepsy

Stereotactic Laser Ablation for Temporal Lobe Epilepsy

SLATE
Start date: December 2016
Phase: N/A
Study type: Interventional

The study is designed to evaluate the safety and efficacy of the Visualase MRI-guided laser ablation system for mesial temporal epilepsy (MTLE).