The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

Telomere Length Clinical Trial

Official title:

The Telomere System in Cord Blood and in the Placenta in High Risk Pregnancies

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT01384136
• Other study ID #: 036-2011 MMC
• Status: Active, not recruiting
• Phase: N/A
• First received: June 27, 2011
• Last updated: June 27, 2011
• Start date: June 2011
• Est. completion date: June 2015

Study information

• Verified date: June 2011
• Source: Meir Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Internal Review Board - Helsinki Committee,Meir Medical Center Kfar Saba, Israel':'Israel: The Israel National Institute for Health Policy Research and Health Services Research
• Study type: Observational

Clinical Trial Summary

The telomere system stabilizes the chromosomes. Telomeres are shortened during senescence, in cases of genetic instability and secondary to stress.

The investigators aim is to study the telomere system in cord blood and in the placenta immediately after the delivery in pregnancies defined as high risk pregnancies following sterss events such as placental insufficiency, preeclampsia, diabetes.

The investigators intend to compare the telomere system in maternal blood to cord blood and to placental biopsies and to study the influence of different stressogenes on this system.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 100
• Est. completion date: June 2015
• Est. primary completion date: June 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Third trimester post delivery

• Intrauterine growth restriction

• Preeclampsia

• Diabetes

• Control - low risk normal pregnancies

Exclusion Criteria:

• Patients who do not want to participate

• Known HIV or Hepatitis

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• High Risk Pregnancies
• Mechanisms of Telomter Homeostasis
• Telomere Length

Locations

Country	Name	City	State
Israel	Meir Medical Center	Kfar Saba

Sponsors (1)

Lead Sponsor	Collaborator
Meir Medical Center

Country where clinical trial is conducted

Israel,