Clinical Trial Details
— Status: Completed
Administrative data
| NCT number |
NCT04104386 |
| Other study ID # |
H11640-33841-01 |
| Secondary ID |
|
| Status |
Completed |
| Phase |
N/A
|
| First received |
|
| Last updated |
|
| Start date |
April 4, 2010 |
| Est. completion date |
November 15, 2011 |
Study information
| Verified date |
September 2019 |
| Source |
University of California, San Francisco |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Interventional
|
Clinical Trial Summary
There is now a critical mass of data linking health to telomere length, and blood telomere
length is starting to become a commercially available measure, with several companies either
offering or planning to offer this measure. With the growing intrigue and interest in
telomeres and its commercial measurement, it is becoming increasingly important to understand
the psychological and behavioral impact of receiving information about one's own telomere
length. Therefore, the primary purpose of this study is to provide results of blood telomere
length (from immune cells) to individuals, and to examine the subsequent psychological and
lifestyle factors associated with learning one's personal results. Specifically, the
investigators will assess if providing both telomere length and educational material on how
cell aging is related to health and how it is modifiable, might lead to improvements in
salutary health behaviors, and consequently, changes in telomere length.
A secondary goal of the study is methodological in nature. Human studies have mainly been
limited to immune cells from blood, which requires a blood draw. The relation between blood
telomere length and telomere length from other cells that are more easily accessible has not
been assessed. Therefore, this study will assess relations between blood telomere length from
venous blood draw with telomere lengths from buccal cells, hair follicle cells, and blood
cells from a finger prick. This study will assess whether a new measure of telomere damage
(TIFS) is related to other measures of cell aging. This study will also assess the
reliability of the venous blood draw telomere length across three different assays (PCR,
southern blot, and fluorescent in situ hybridization or FISH). To meet these aims, this study
will collect samples of these cells from 240 healthy volunteers from the community.
Description:
Background and Significance: Briefly sketch the scientific background leading to the present
proposal, critically evaluate existing knowledge (with references), and specifically identify
the gaps the project is intended to fill. State concisely the importance and health relevance
of the research described in this application by relating the specific aims to the broad,
long-term objectives.
Background and Rationale for Study:
There is now a comprehensive amount of data linking physical health to telomere length.
Because of this, telomere length is becoming a commercially available measure. Several
companies offer or plan to offer this measure; Spectracell Laboratories (www.spectracell.com)
is one example of such a company. In order to have one's own telomere length measured, it's
as easy as putting a zip code into a search function on their website to find the
geographically closest clinician that will order the test. It is thus important to consider
that there are no studies that have examined the possible responses to learning one's
telomere length, whether it might be helpful or not, or even harmful. Learning about one's
telomere length may motivate healthy behaviors, such as exercise or smoking cessation. The
likely possibility of people learning their telomere length diagnostically in the future, and
the potential for both positive and negative effects of learning this information, provide a
strong rationale for studying the psychological and behavioral effects of learning one's
telomere length.
Telomere length is a risk factor for disease:
Telomere length has become a valuable risk factor, as it is now linked to and predictive of
many diseases and early mortality. For example, being of below average TL in a healthy
population predicts threefold risk of earlier mortality in two studies. This effect size is
comparable to other well accepted risk factors. Telomere shortening in these cases is likely
acquired from lifetime exposures (lifestyle, cigarette smoking, infections) as well as from
some presumably smaller genetic influence.
Telomeres can be very short from genetic/inherited conditions, and thus telomere testing can
be helpful in the future to identify risk for rare genetically influenced conditions. Those
with very short TL, probably in the bottom 5 to 10 percentile, are at risk of having a
genetic defect in their genes that make telomerase (hTERT and hTR), and they may end up with
haplosufficiency or half the normal dose of telomerase, which is not enough to protect
telomeres from shortening. These defects are associated with short telomere syndromes,
including liver fibrosis, lung fibrosis, bone marrow failure (aplastic anemia), poor immune
function, and increased risk for cancers. Pulmonary Fibrosis (scarring of the lungs), a
disease of aging which afflicts around 5 million people world wide, is characterized by short
telomeres, and up to 15% of families with this condition have mutations in these genes for
telomerase. Similarly, 3% of adults with aplastic anemia have telomerase mutations as well.
If unrecognized and untreated, aplastic anemia quickly leads to death.
In sum, given the role of telomere shortening in common diseases, the evidence that healthy
lifestyle behaviors are associated with longer telomere length, and the clear role of very
short telomeres in rare conditions, telomere testing can potentially provide benefit to
individuals.
Primary Aim 1: To assess whether learning one's personal blood telomere length (from immune
cells) can have a positive impact on one's health behaviors and lifestyle factors (body
weight, food choices, vitamin use, stress levels, and exercise). The investigators will
further assess whether lifestyle and health behavior changes are related to subsequent
changes in telomere length.
Telomere length has become commercially available and may become widely available in the
coming years. Telomere length is a new biomarker that may or may not be helpful to know. It
is related to lifestyle factors. The investigators have found high perceived stress is
related to shorter TL, which several other labs have replicated, and the investigators now
find that exercise buffers this relationship. Specifically, those high stress individuals who
do vigorous exercise do not show shorter telomeres. Telomeres can also lengthen over time, as
evidenced by recent evidence and the investigators unpublished data. A study found that
improvements in lifestyle (including nutrition, stress reduction, and weight loss) were
associated with increases in telomerase, the enzyme that lengthens telomeres. The
investigators' unpublished data also shows that those who show decreases in stress over one
year have increases in telomere length during this period, with a correlation of r = -.44.
The investigators thus expect that improvements in lifestyle and stress levels can lengthen
or at least forestall shortening of telomeres, and with a sample size of 240, the
investigators can test these associations.
While the investigators are aiming to examine the behavioral and lifestyle effects of
telomere length disclosure, of concern is whether receiving information about one's own blood
telomere length could have a negative psychological impact. These concerns are quite valid,
and a primary purpose of the present study, then, is to also examine the impact of finding
out about one's blood telomere length on one's psychological well-being.
The investigators draw from a relevant study in the field of Alzheimers. In a 2009 study,
investigators randomized 162 adult children of parents with Alzheimer's disease (thus at high
risk of Alzheimers) to either a disclosure group, where they learned whether or not they
tested positive for ApoE allele, a susceptibility risk factor for Alzheimer's Disease, and a
nondisclosure group, where they did not learn of their results (The REVEAL trial). They
measured anxiety, depression, and test anxiety at three points over the next year. Among
those in the disclosure group, those who tested positive showed slightly greater test-related
distress than the negative group, but the difference was not clinically meaningful. The
findings support the psychological safety of disclosing genetic risk factor data, at least in
this specific case.
More relevant to the investigators' current design was the REVEAL trial's primary outcome--
whether there were significant differences between the disclosure group and the nondisclosure
group in distress. Importantly, there were no significant differences in measures of distress
between the disclosure and nondisclosure groups. Further, those who discovered they were
APOE-negative experienced psychological relief, showing lower test related distress compared
to those who received no information about their APOE-negative status at 6 months. These
results suggest that individuals who discover a genetic vulnerability to a disease are no
more likely to experience psychological distress, and that those who are at no considerable
risk actually experience relief, it is important to examine such processes related to a
marker like telomere length which has been linked to a wide array diseases and disorders.
Learning about a risk factor like telomere length may or may not cause distress. The
investigators' primary aim is to examine how being told one's own personal blood telomere
length affects a person behaviorally and psychologically. The investigators expect it will
cause only mild transient distress (slight increase on anxiety) if any, for those who are
told they have short telomeres (bottom 25%). It is a susceptibility factor rather than a
deterministic risk factor. In addition, learning about one's blood telomere length provides
an opportunity for one to make behavior changes to improve blood telomere length, in contrast
to a genetic risk factor that cannot change. Therefore, the investigators expect that people
with short telomeres may be more motivated to increase healthy behaviors over the ensuing
months. The investigators will emphasize that telomere length is changeable, and list the
health behaviors that are associated with telomere length and thus may be linked to
improvements in blood telomere length in a 'telomere information sheet.'
Behavior may change merely as a result of learning about the importance of telomeres and how
they can take measures to protect their telomeres (in the "telomere information sheet"),
regardless of knowing one's personal results. Therefore, it is necessary to have a control
group for this educational portion of the study. Therefore, the investigators randomize one
group to learn their telomere length only at the end of the study so that they can serve as a
'no result' control group for the study while the investigators assess behavior changes.
In addition to assessing emotional response when they are informed of their personal results,
in the experimental group, the investigators will also assess whether the volunteers have
made any changes in their health behaviors and lifestyle at either a 3 Month Follow-Up or 9
Month Follow-up from disclosure. The investigators will further examine, at 9 Month
Follow-up, telomere length, by having participants return to the lab for a final blood draw.
The investigators expect telomere length to change as a function of health behaviors and
lifestyle changes that are undertaken and maintained throughout the 10 month period.
