Demonstration of the Presence of a Carbonyl Stress in the Hair Follicles of Postpartum Women

Telogen Effluvium Clinical Trial

Official title: Demonstration of the Presence of a Carbonyl Stress in the Hair Follicles of Postpartum Women

Status Completed

Clinical Trial Summary

In this study, the investigator will try to highlight the presence of carbonyl compounds in the hair follicles of postpartum women by comparing these compounds before and after delivery.

Clinical Trial Description

At the cutaneous level, oxidative stress induces the formation of carbonyl compounds which, by binding to proteins, produce non-functional adducts inducing cutaneous aging. This mechanism is called "carbonyl stress".

During pregnancy, estrogen increases massively, stimulates the whole body and prolongs the life of the hair (slower passage in telogen phase).

After delivery, estrogen levels drop, resulting in a massive and simultaneous hair loss that should have "naturally" fallen earlier. In addition, birth is a stressful stage for most moms. This stress and excessive fatigue and possibly a return to work may also be responsible for hair loss.

Is the carbonyl stress also present in the scalp and can it be one of the mechanisms involved in the occurrence of postpartum hair loss? To demonstrate this, samples of hair follicles are taken. The proteins are extracted from the samples and then assayed. The oxidized (carbonyl) proteins are labeled with specific fluorescent probes ;

Related Conditions & MeSH terms

• Telogen Effluvium

• NCT number: NCT04237402
• Study type: Interventional
• Source: Pierre Fabre Dermo Cosmetique
• Status: Completed
• Phase: N/A
• Start date: June 15, 2018
• Completion date: December 16, 2019