Tattoo Particles: Picosecond Laser Versus Nanosecond Laser

Tattoo; Pigmentation Clinical Trial

Official title:

In Vivo Analysis of Tattoo Particles After Picosecond Laser Compared to Nanosecond Laser

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06431464
• Other study ID #: 02-24
• Status: Recruiting
• Start date: February 1, 2024
• Est. completion date: July 31, 2024

Study information

• Verified date: May 2024
• Source: Universitätsklinikum Hamburg-Eppendorf
• Contact: Lynhda Nguyen, Dr. med.
• Phone: +49 (0) 7410-0
• Email: l.ngyuen[@]uke.de
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

- For treating unwanted tattoos, the gold standard treatment is a nanosecond or picosecond laser. However, comparative microscopic analysis is limited. Therefore, the aim of the present study is to analysis morphological changes of tattoo particles and surrounding tissue in human skin.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 20
• Est. completion date: July 31, 2024
• Est. primary completion date: June 30, 2024
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• healthy patients who plan a laser treatment of their unwanted tattoo/ tattoos at our department

Exclusion Criteria:

• laser pretreatment of their tattoos to be treated

• pregnancy, breast feeding

• open wound on the area to be treated

Related Conditions & MeSH terms

• Tattoo; Pigmentation

Intervention

Other:
• picosecond laser treatment + measurement with a multiphoton tomography system
Patients with unwanted tattoos who plan a laser treatment will be recruited for measurements using a multiphoton-tomography system. These are scheduled 6 weeks and 12 weeks post-treatment.
• nanosecond laser treatment + measurement with a multiphoton tomography system
Patients with unwanted tattoos who plan a laser treatment will be recruited for measurements using a multiphoton-tomography system. These are scheduled 6 weeks and 12 weeks post-treatment.

Locations

Country	Name	City	State
Germany	University Medical Center Hamburg-Eppendorf	Hamburg

Sponsors (1)

Lead Sponsor	Collaborator
Universitätsklinikum Hamburg-Eppendorf

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Nguyen L, Mess C, Schneider SW, Huck V, Herberger K. In vivo visualisation of tattoo particles using multiphoton tomography and fluorescence lifetime imaging. Exp Dermatol. 2022 Nov;31(11):1712-1719. doi: 10.1111/exd.14646. Epub 2022 Jul 25. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Size of intercellular spaces	Size of intercellular spaces after picosecond or nanosecond laser treatment.	6 weeks and 12 weeks post-treatment
Primary	Size of keratinocytes	Size of keratinocytes after picosecond or nanosecond laser treatment.	6 weeks and 12 weeks post-treatment
Primary	Size of tattoo particles	Size of tattoo particles after picosecond or nanosecond laser treatment.	6 weeks and 12 weeks post-treatment
Primary	Distribution of tattoo particles	Distribution though the epidermal and dermal layers after picosecond or nanosecond laser treatment.	6 weeks and 12 weeks post-treatment