Taste Disorders Clinical Trial
Official title:
The Structure and the Function of the Taste Buds After the Stapes Surgery and the Patients Quality of Life and it's Correlation to the Change of the Threshold of the Chorda Tympani Electrical Stimulation
Patients admitted for the otosclerosis operation are included in the study. The Narrow Band Imaging (NBI) of their taste buds is performed before the operation. The sensory function of the anterior 2/3 of the tongue is tested with the two point discrimination discs, the taste is tested with taste strips and the SF-36 questionnaire is applied. During the operation in local anesthesia the threshold for the tongue sensation (by the stimulation of the chorda tympani nerve) of the first 2/3 of the tongue at the beginning of the operation (when we first encounter the chorda tympani nerve) and at the end of the operation is measured.One month and six months after the operation the tests are being repeated (NBI, two-point discrimination and SF-36 questionnaire). The study has the National Ethical Committee approval.
Patients admitted for otosclerosis operation 18 to 65 years old, not taking medications that could influence the taste and not having the problems with the smell are being recruited for the study. The informed consent is signed by the patient. The Narrow Band Imaging (NBI) of their taste buds is performed before the operation. The number of taste buds in the 20mm2 size area and the blood vessel morphology is being recorded. For the blood vessel morphology the five point scoring system is used. Both sides of the tongue are tested separately. The sensory function of the anterior 2/3 of the tongue is tested with the two point discrimination discs. Both sides of the tongue are tested separately. The taste strips are used with 4 different concentrations of sweet, sour, salty and bitter applied to each side of the tongue separately. SF-36 questionnaire adapted to Slovenian language is applied. During the operation in local anesthesia the threshold for the tongue sensation at the beginning of the operation (when the investigators first encounter the chorda tympani nerve) and at the end of the operation is measured. The investigators use the facial nerve monitoring system for the measurements and stimulate directly the chorda tympani with electrical current. After each operation the surgeon determines the grade of the intraoperative manipulation of the chorda tympani nerve. One month and six months after the operation the tests are being repeated (NBI, two-point discrimination, taste testing with taste strips and SF-36 questionnaire). The study has the National Ethical Committee approval. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04532632 -
Taste and Smell Impairment in Critically Ill COVID-19 Patients
|
||
Completed |
NCT04145453 -
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults
|
N/A | |
Recruiting |
NCT02931812 -
Feeding Behavior and Taste Sensitivity Before and After Liver or Renal Transplantation
|
||
Not yet recruiting |
NCT04661800 -
Study of Olfactory Disorders in Patients With Cardiac Amyloidosis
|
N/A | |
Completed |
NCT04302792 -
New Food Solutions for Cancer Patients
|
N/A | |
Withdrawn |
NCT05760079 -
Lactoferrin for COVID-19-Induced Taste or Smell Abnormality
|
N/A | |
Completed |
NCT03196440 -
Sensitivity of Basic Taste in Elderly
|
||
Completed |
NCT04235153 -
CAncer, NUtrition and Taste - Validation of the CANUT-QVA Questionnaire on Eating Habits in Cancer Patients
|
||
Recruiting |
NCT02304913 -
Hypoglossal Acupuncture for Dysgeusia in Patients Undergoing Chemotherapy
|
N/A | |
Completed |
NCT04543175 -
Taste Disorders and Their Relation to BMI, FFQ, and EORTC QLQ-BR23 in Breast Cancer Patients During Chemotherapy.
|
||
Completed |
NCT04923321 -
Taste Supra-thresholds Among a Sample of Depressed Egyptian Adult Under Anti-depressants Therapy
|
||
Completed |
NCT04923425 -
Gustatory Modulators Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy
|
||
Completed |
NCT03599011 -
Gustatory Dysfunction Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy
|
||
Completed |
NCT03498950 -
Changes in Sense of Taste of Patients Submitted to Hematopoietic Stem Cell Transplantation
|
N/A | |
Withdrawn |
NCT03043144 -
Taste And Smell TEsting in End Stage Renal Disease
|
N/A | |
Recruiting |
NCT06456008 -
Prospective Registery of Smell/Taste Clinic Ear/Nose/Throat
|
||
Not yet recruiting |
NCT05104424 -
The Study of Quadruple Therapy Intranasal Insulin, Zinc, Gabapentin, Ice Cube Stimulation for Post COVID-19 Smell and Taste Dysfunctions
|
Phase 1 | |
Completed |
NCT01540045 -
Effect of Chemotherapy With Paclitaxel/Cisplatin on Development Dysgeusia in Non Small Cell Lung Cancer
|
||
Completed |
NCT05227157 -
GOUTMETALSAIN: Comparison of the Perception of Metallic Taste According to Lingual Locations in Healthy Volunteers
|
||
Completed |
NCT00316563 -
Orexigenic Therapy With Delta-9-tetrahydrocannabinol in Advanced Cancer Patients With Chemosensory Abnormalities - a Pilot Study
|
Phase 2 |