Interaction of Inflammation, Taste Perception and Preferences as a Function of Physical Activity and Body Composition

Taste, Altered Clinical Trial

Official title:

Interaktion Von ausgewählten Inflammationsparametern, Geschmackswahrnehmung Und Geschmackspräferenzen in Abhängigkeit Von Physischer Aktivität Und Körperzusammensetzung

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06384365
• Other study ID #: 706014-4
• Status: Recruiting
• Start date: April 15, 2024
• Est. completion date: April 30, 2025

Study information

• Verified date: April 2024
• Source: University of Vienna
• Contact: Barbara Lieder, PhD
• Phone: 4314277
• Email: Barbara.Lieder[@]univie.ac.at
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to investigate whether differences in taste perception and preference behavior can be attributed to inflammatory processes induced by physical activity. The focus will be on sweet taste and the perception of fat. A non-invasive, observational study design will be used.

Description:

This study adresses the question of whether there is a connection between low-grade inflammation caused by physical activity and a change in taste perception and preference for the sweet taste. The taste perception, preference behavior and inflammation in athletic and healthy non-athletic subjects using an observational study design is investigated. The hypothesis is that athletic test subjects, compared to healthy, physically inactive subjects, show increased inflammation values, in the range of a low-grade inflammation, and that this results in a lower sensitivity and increased preference for sweet taste. The primary parameters to be investigated are a possible correlation between the level of physical activity physical activity or body composition and the recognition threshold for the sweet taste as well as the preference. In addition, a correlation between the concentration of TNF-α and IL-6 in saliva sweet recognition threshold and sweet preference will be investigated. Secondary parameters to be analyzed are the preference for fatty substances, the perception threshold for the perception threshold for the fatty taste, taste receptors in saliva for the sweet and fatty taste, the concentration of 8-epi-PGF2α in the urine as a marker for oxidative stress, and the number of fungiform papillae on the tongue are determined.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 66
• Est. completion date: April 30, 2025
• Est. primary completion date: September 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• healthy
• non-smoking
• normal taste and smell perception

Exclusion Criteria:

• pregnancy or breast-feeding
• regular smokers
• regular intake of medication
• metabolic diseases that require drug therapy
• ageusia or anosmia
• alcohol or drug addiction
• intake of antibiotics within the past 2 months
• vegan diet
• viral or bacterial infection wihtin the past three weeks

Related Conditions & MeSH terms

• Dysgeusia
• Taste, Altered

Intervention

Behavioral:
• Physical activity
The control and the athletic group differ in the degree of physical acitvity

Locations

Country	Name	City	State
Austria	Christian Doppler Laboratory for Taste Research	Vienna

Sponsors (1)

Lead Sponsor	Collaborator
University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Taste sensitivity	detection threshold for sweet and fatty taste analysed using a 3-AFC test	day 1
Primary	Taste preference	preference for sweet and fatty taste analyzed by means of a Food Frequency Questionnaire and food choices from a standardized breakfast	day 1
Primary	Body composition	body fat percentage	day 1
Primary	Low-grade inflammation	Concentration of interleukin 6 and tumor necrosis factor alpha in unstimulated saliva	day 1
Secondary	Oxidative Stress	8-epi-PGF2a analysis in urine	day 1
Secondary	fungiform papillae density	The number of fungiform papillae in a definded area of 1 cm² at the tip of the tongue is counted after staining of the tomgue with methylene blute	day 1