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Life-style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy — BREAKOUT  

Takotsubo Cardiomyopathy Clinical Trial

Official title:
Life-Style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy - the BREAKOUT Study

Clinical Trial Summary

Takotsubo cardiomyopathy presents like a heart attack and is typically triggered by intense emotional or physical stress. Recovery of this condition varies and many patients continue to suffer from symptoms such as fatigue and breathlessness for a protracted period after their event. The purpose of this study is to establish whether following a structured exercise program or a mental wellbeing program compared to usual care for 12 weeks after an episode of Takotsubo will result in significant improvement in the brain activity, general and mental wellbeing of patients.

Clinical Trial Description

Takotsubo cardiomyopathy is characterised by sudden onset left ventricular dysfunction precipitated by major stress. This neuro-cardiac condition has a 5-year morbidity and mortality comparable with acute myocardial infarction and no current therapies exist. The psycho-somatic basis of Takotsubo suggests that its neuro-biology could be amenable to modulation. Here, the investigators propose a mechanistic three-arm pilot feasibility trial of standardised physical exercise training, cognitive behavioural therapy and current standard of care in patients who suffered a very recent episode of takotsubo cardiomyopathy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05530135
Study type Interventional
Source University of Aberdeen
Contact
Status Completed
Phase N/A
Start date October 6, 2020
Completion date August 31, 2023
View Details
See also
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