Takotsubo Cardiomyopathy Clinical Trial
— GENETICOfficial title:
Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy: The GENETIC Study
Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.
Status | Recruiting |
Enrollment | 700 |
Est. completion date | December 31, 2028 |
Est. primary completion date | December 31, 2028 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - All patients who have been diagnosed with Takotsubo cardiomyopathy in Scotland between 2010 to date. - Familial cases elsewhere in the world who would be willing to participate. Exclusion Criteria: - Unwillingness to participate |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Cardiovascular Research Facility | Aberdeen | Aberdeenshire |
Lead Sponsor | Collaborator |
---|---|
University of Aberdeen |
United Kingdom,
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Scally C, Rudd A, Mezincescu A, Wilson H, Srivanasan J, Horgan G, Broadhurst P, Newby DE, Henning A, Dawson DK. Persistent Long-Term Structural, Functional, and Metabolic Changes After Stress-Induced (Takotsubo) Cardiomyopathy. Circulation. 2018 Mar 6;137(10):1039-1048. doi: 10.1161/CIRCULATIONAHA.117.031841. Epub 2017 Nov 11. — View Citation
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* Note: There are 21 references in all — Click here to view all references
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Primary | Genome Wide Association Study | Genome Wide Association Study to search for susceptibility variants | At baseline |
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