Clinical Trials Logo

Clinical Trial Summary

Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.


Clinical Trial Description

Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04513054
Study type Interventional
Source University of Aberdeen
Contact Amelia E Rudd, MSc
Phone 01224559473
Email a.e.rudd@abdn.ac.uk
Status Recruiting
Phase N/A
Start date March 12, 2019
Completion date December 31, 2028

See also
  Status Clinical Trial Phase
Recruiting NCT04325321 - The Broken Heart Study II (BHS-II) N/A
Recruiting NCT03663348 - Registry of Patients With Takotsubo Syndrome
Recruiting NCT04695587 - The Role of Sympathetic Tone Regarding the Anatomical and Functional Recovery of the Left Ventricle in TakoTsubo Syndrome
Completed NCT05530135 - Life-style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy N/A
Not yet recruiting NCT05946772 - Cyclosporine In Takotsubo Syndrome Phase 2
Completed NCT02240056 - Brain fMRT In Takotsubo Cardiomyopathy
Completed NCT02307214 - Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: New Insights Into the Pathophysiology N/A
Recruiting NCT05977049 - Psychosocial Support for Patients With Takotsubo Syndrome N/A
Recruiting NCT06277297 - Prognotic Role of CMR in Takotsubo Syndrome
Completed NCT03787810 - Left Ventricular Dysfunction in Critically Ill Patients
Active, not recruiting NCT00123695 - Serial Echocardiography After Subarachnoid Hemorrhage N/A
Recruiting NCT05793008 - Characterization of priMary And sEcondary STress Related takOtsubo N/A
Completed NCT04425785 - Physical Exercise and Mental Wellbeing Rehabilitation for Acute Stress-induced Takotsubo Cardiomyopathy: The PLEASE Study N/A
Recruiting NCT02361073 - The Role of Emotional Stress in Patients With Stress-induced Cardiomyopathy N/A
Recruiting NCT06323811 - Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics N/A
Recruiting NCT03299569 - Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland
Recruiting NCT01947621 - International Takotsubo Registry (InterTAK Registry) N/A
Completed NCT04684004 - Hyperglycemia in Patients With Takotsubo Syndrome
Completed NCT02759341 - Brain-heart Interactions in Tako-Tsubo Cardiomyopathy and Cardiac Syndrome X: N/A
Completed NCT02659878 - Takotsubo Cardiomyopathy in Patients Suffering From Acute Non-traumatic Subarachnoid Hemorrhage