Takotsubo Cardiomyopathy Clinical Trial
Official title:
Pilot Study: Central Nervous System and Hormonal Changes In Takotsubo Cardiomyopathy
Certain cardiac and neurologic diseases influence each other via a still poorly understood
"brain-heart axis". Subarachnoidal bleedings are well known to cause ECG alterations
resembling those of myocardial infarction, along with a reduction of systolic myocardial
function ("neurogenic stunned myocardium"). Alterations of the right insula region by a
stroke or intracranial hemorrhage go along with a sympathetic activation (increased
circulating catecholamine levels, tachycardia, arterial hypertension). In contrast,
alterations of the left insula region often cause vagal reactions such as bradycardia,
arterial hypotension. Takotsubo cardiomyopathy (TTC) is a just recently recognised subform of
heart attacks, often caused by psychological or physical stress (death of a beloved one,
divorce, job loss, infection, preoperative state). In more than 90% of cases, TTC affects
postmenopausal women.
Functional MRT enables imaging of activated brain regions, either without ("resting state")
or with specific stimuli. The investigators speculate that there is a specific involvement of
the insula region during TTC.
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