Subarachnoid Hemorrhage Clinical Trial
Official title:
Serial Echocardiography After Subarachnoid Hemorrhage (S.E.A.S.)
There is increasing interest in myocardial abnormalities following central nervous system
events, such as subarachnoid hemorrhage (SAH). These cardiac abnormalities include ECG
changes, decreased cardiac output, decreased blood pressure, specific cardiac enzyme
elevations, and segmental wall motion abnormalities (SWMA). Interestingly, wall motion
abnormalities and ECG changes have shown to be reversible, and therefore the dysfunction has
been described as neurogenic myocardial stunning.
The pathophysiology of cardiac dysfunction following SAH has not yet been fully elucidated.
Many reports (mainly case reports) have been published, but so far no study has investigated
the frequency of these abnormalities in a prospective manner, have correlated the occurrence
of the different cardiac abnormalities, and have assessed which clinical variables can
predict cardiac dysfunction. And only a limited number of studies have related neurological
outcome with cardiac dysfunction.
Objectives: Therefore, our study objectives are: 1) Assessment of the frequency of
myocardial dysfunction (segmental wall motion abnormalities, cardiac-specific enzyme
elevations, and ECG changes) in patients with SAH. 2) Determination of predictive clinical
variables for the occurrence of myocardial dysfunction following SAH. 3) Impact of
myocardial dysfunction on neurological prognosis: death, secondary cerebral ischemia,
hydrocephalus and rebleeding.
Methods: For this purpose serial echocardiograms and ECGs will be obtained and cardiac
enzymes will be measured in 200-400 patients admitted to hospital with SAH in the four
participating centers. The clinical variables that will be studied to predict cardiac
dysfunction are: medical history, the CT-scan score, circulatory parameters, blood samples,
medication, surgical intervention (coiling or clipping), and the neurological condition
(Glasgow Coma Scale). The echocardiograms, ECGs and cardiac enzymes will be studied to
determine if they have independent prognostic value for the outcome in SAH patients.
Expected Results: As ECG changes and drops in blood pressure are known to occur frequently,
the researchers expect to find that cardiac contractile dysfunction in patients with SAH
occurs more frequently than is assumed now. Moreover, if cardiac abnormalities have
neurological prognostic significance further studies are needed for early recognition and
treatment of the cardiac abnormalities in SAH, a condition with a very poor prognosis.
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Observational Model: Cohort, Time Perspective: Prospective
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