Tactile Perception Clinical Trial
Official title:
The Causal Role of Neocortical Beta Events in Human Sensory Perception
Low-frequency brain rhythms in the alpha (8-14Hz) and beta (15-29Hz) bands are strong predictors of perception and functional performance in a range of tasks, and are disrupted in several disease states. The purpose of this study is to investigate a direct causal relationship between low-frequency brain rhythms and sensory perception, and to optimize commonly used TMS paradigms to impact sensory processing and perception in a similar manner as endogenous rhythms. To do so, this study combines human magnetic resonance imaging (MRI), electroencephalography (EEG), non-invasive brain stimulation (transcranial magnetic stimulation; TMS), and biophysically principled computational neural modeling.
Status | Recruiting |
Enrollment | 25 |
Est. completion date | January 31, 2022 |
Est. primary completion date | January 31, 2022 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Ability to provide informed consent/assent - Age: 18-65 years - English fluency: participants must be able to understand screening questionnaires and task instructions spoken/written in English. - Right handed: to reduce heterogeneity related to hand dominance, since our task involves touch perception on the hand, and examination of neural correlates in lateralized brain regions. Exclusion Criteria: - History of fainting spells of unknown or undetermined etiology that might constitute seizures - History of seizures, diagnosis of epilepsy, or immediate (1st degree relative) family history epilepsy - Any progressive (e.g., neurodegenerative) neurological disorder - Chronic medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.) - Metal implants (excluding dental fillings) - Pacemaker - Implanted medication pump or cochlear implant - Vagal nerve stimulator - Deep brain stimulator - TENS unit (unless removed completely for the study) - Ventriculo-peritoneal shunt - Signs of increased intracranial pressure - Intracranial lesion - History of head injury resulting in prolonged loss of consciousness - Pregnancy - Participants who have received prior TMS for medical treatment purposes. - Intellectual Disability or autism spectrum disorder (ASD) - Active psychosis, diagnosis of unipolar depression or bipolar disorder, active severe substance use disorders (within the last month), or active suicidal intent or ideations. - Conditions that may result in the inability to effectively carry out the tactile detection task, including loss of feeling, neuropathy or nerve damage in the hands or feet, chronic pain or fibromyalgia, and pain due to cancer, infection or arthritis. - If the participant is actively taking any of the medications that increase risk from TMS as indicated below, of if they have ingested any alcohol or any other drugs of abuse (see https://www.drugabuse.gov/drugs-abuse) on the day of the study session (prior to the session). Contraindicated medications: alcohol Amitriptyline Amphetamines ampicillin Anticholinergics Antihistamines aripiprazole BCNU **bupropion** cephalosporins chlorambucil chloroquine Chlorpromazine citalopram Clozapine Cocaine cyclosporine cytosine arabinoside Doxepine duloxetine fluoxetine fluphenazine fluvoxamine Foscarnet gamma-hydroxybutyrate (GHB) Ganciclovir haloperidol imipenem Imipramine isoniazid ketamine levofloxacin Lithium Maprotiline MDMA (ecstasy) mefloquine methotrexate metronidazole mianserin mirtazapine Nortriptyline olanzapine paroxetine penicillin phencyclidine (PCP, angel's dust) pimozide quetiapine reboxetine risperidone Ritonavir **Sertraline** Sympathomimetic theophylline venlafaxine vincristine ziprasidone |
Country | Name | City | State |
---|---|---|---|
United States | Brown University, Carney Institute for Brain Science Human Testing Space (HuTS) | Providence | Rhode Island |
Lead Sponsor | Collaborator |
---|---|
Brown University | National Institute of General Medical Sciences (NIGMS) |
United States,
Jones SR, Kerr CE, Wan Q, Pritchett DL, Hämäläinen M, Moore CI. Cued spatial attention drives functionally relevant modulation of the mu rhythm in primary somatosensory cortex. J Neurosci. 2010 Oct 13;30(41):13760-5. doi: 10.1523/JNEUROSCI.2969-10.2010. — View Citation
Jones SR, Pritchett DL, Sikora MA, Stufflebeam SM, Hämäläinen M, Moore CI. Quantitative analysis and biophysically realistic neural modeling of the MEG mu rhythm: rhythmogenesis and modulation of sensory-evoked responses. J Neurophysiol. 2009 Dec;102(6):3554-72. doi: 10.1152/jn.00535.2009. Epub 2009 Oct 7. Erratum in: J Neurophysiol. 2014 Dec 15;112(12):3251. — View Citation
Jones SR, Pritchett DL, Stufflebeam SM, Hämäläinen M, Moore CI. Neural correlates of tactile detection: a combined magnetoencephalography and biophysically based computational modeling study. J Neurosci. 2007 Oct 3;27(40):10751-64. — View Citation
Sherman MA, Lee S, Law R, Haegens S, Thorn CA, Hämäläinen MS, Moore CI, Jones SR. Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4885-94. doi: 10.1073/pnas.1604135113. Epub 2016 Jul 28. — View Citation
Shin H, Law R, Tsutsui S, Moore CI, Jones SR. The rate of transient beta frequency events predicts behavior across tasks and species. Elife. 2017 Nov 6;6. pii: e29086. doi: 10.7554/eLife.29086. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Threshold-level tactile detection | Participants receive one tactile stimulus per trial and report detection or non-detection using a button press. Stimuli are delivered at one of three intensities: perceptual threshold-level (70% of trials), suprathreshold-level (always perceived, 10% of trials) or null stimuli (no stimulus, 20% of trials). | Measures of tactile detection are collected during the tactile detection task, which is assessed on each study visit (with the exception of an MRI-only visit) throughout the course of study completion, an average of 6-12 months. | |
Primary | EEG tactile evoked response potential (ERP) | Participants receive one tactile stimulus per trial concurrent with EEG recording. The EEG-measured ERP immediately following each tactile stimulus is assessed and compared across conditions. | EEG measures are collected during the tactile detection task, which is assessed on each study visit (with the exception of an MRI-only visit) throughout the course of study completion, an average of 6-12 months. |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05013814 -
The Effect of Tactile Deficit on Motor Function in Unilateral Cerebral Palsy
|
||
Recruiting |
NCT06231810 -
Tracking a Tactile Signal Along the Nervous System
|
N/A |