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NCT05086510 Clinical Trial

Ablation Targets of Scar-related Ventricular Tachycardia Identified by Dynamic Functional Substrate Mapping

Tachycardia, Ventricular Clinical Trial

Official title:
Ablation Targets of Scar-related Ventricular Tachycardia Identified by Dynamic Functional Substrate Mapping

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05086510
Other study ID # FMASUMD83/2021
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date October 28, 2021
Est. completion date June 26, 2023

Study information
Verified date July 2023
Source Ain Shams University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study aims at comparing the recurrence rates of ventricular tachycardia ablated after being mapped by 2 different techniques.

Description:

The study participants are patients presented with recurrent ventricular tachycardia. They will be divided into 2 groups in terms of mapping. The first group will use mapping during sinus rhythm to identify late potentials that may be incriminated in the tachycardia circuit. The other group will undergo mapping during right ventricular extrastimulus pacing to unmask hidden potentials. The identified potentials will be ablated in both groups.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date June 26, 2023
Est. primary completion date June 26, 2023
Accepts healthy volunteers No
Gender All
Age group N/A and older
Eligibility Inclusion Criteria: - • Patients with structural heart disease; previous myocardial infarction, left ventricular dilatation/systolic dysfunction, or normal left ventricular diameters/ systolic function with evidence of ventricular scar on contrast enhanced-cardiac magnetic resonance or electroanatomic map. - Sustained monomorphic ventricular tachycardia documented by 12-lead ECG or implantable cardioverter defibrillator (electrograms resistant to antiarrhythmic drug treatment or requiring implantable cardioverter defibrillator therapies. Exclusion Criteria: - • Patients with ventricular arrhythmias attributed to reversible causes.

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Radiofrequency ablation
Both groups will undergo radiofrequency ablation of potentials likely responsible for the tachycardia. Those potentials are identified by the formentioned 2 distinct methods.

Locations
Country Name City State
Egypt AinShams university hospitals Cairo

Sponsors (1)
Lead Sponsor Collaborator
Ain Shams University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of Participants With Recurrence of Ventricular Tachycardia Recurrence of ventricular tachycardia implies receiving at least one appropriate implantable cardioverter defibrillator therapy or hospital admission due to symptomatic ventricular tachycardia. 12 months
Secondary Number of Participants Who Experience Cardiac Death This is defined as unexpected death where a cardiac cause is the most probable etiology 12 months
Secondary Number of Participants Who Die From Any Cause (All-cause Mortality) This includes death from any cause 12 months
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