T2D Clinical Trial
Official title:
Pathogenesis of Youth Onset Type 2 Diabetes and Prediabetes
Type 2 Diabetes (T2D) in obese youth is often preceded by a prediabetic state called: Impaired Glucose Tolerance (IGT), which is associated with a pre-existing defect in insulin secretion. This study intends to determine if genetic factors are associated with defects in insulin secretion, the incretin system and hepatic insulin resistance in obese adolescents. The long-term goal of this study is to generate information on both the genetics as well as the pathophysiology of Type 2 Diabetes in Youth, which ultimately might guide the investigators towards better preventive and treatment avenues.
The Specific Aims of this study are: Aim 1a. To delineate the effects of TCF7L2 rs7903146 on functional Beta-Cell Capacity in obese adolescents with Impaired Glucose Tolerance (IGT) and pre-IGT. Aim 1b. To determine if the risk genotype in TCF7L2 is associated with worsening in beta cell function longitudinally, thereby affecting changes in glucose tolerance. Aim 2. To examine the functional effect of the rs7903146 variant in the TCF7L2 gene on a) incretin effect in obese adolescents with IGT and pre-IGT. Aim 3. To determine the functional effects of TCF7L2 rs7903146 SNP on hepatic glucose fluxes in obese adolescents with IGT and pre-IGT. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03194152 -
Peanut Consumption and Cardiovascular Disease Risk in a Chinese Population
|
N/A | |
| Enrolling by invitation |
NCT05760677 -
Study on the Efficacy and Safety of Chiglitazar Sodium in PCOS With T2DM
|
Phase 1 | |
| Not yet recruiting |
NCT05980754 -
Clinical Study on Exploring High Risk Factors Inducing the Progress of Diabetes
|
||
| Recruiting |
NCT04501341 -
BM-MNC and UCMSC for Type 2 Diabetes Mellitus Patients
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT05662332 -
A Study of Insulin Efsitora Alfa (LY3209590) Compared to Glargine in Adult Participants With Type 2 Diabetes Who Are Starting Basal Insulin for the First Time (QWINT-1)
|
Phase 3 | |
| Recruiting |
NCT05536804 -
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
|
Phase 2 | |
| Completed |
NCT04011904 -
The Role of Traditional or Western Diet in the TBC1D4 Gene on Glucose Homeostasis in Greenland Inuits
|
N/A | |
| Active, not recruiting |
NCT05260021 -
A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both
|
Phase 3 |