SYSTEMIC REACTION Clinical Trial
— chackosOfficial title:
Systemic Reactions to Allergen Immunotherapy Amd Skin Testing
Verified date | July 2008 |
Source | University of South Florida |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
Allergy skin tests and allergen immunotherapy are common procedures for both the diagnosis
and treatment of atopic diseases. Allergen immunotherapy has proved to be effective in
reducing the symptoms of allergic rhinitis and asthma1-2. Despite its clinical benefit,
there is risk of systemic reactions associated with these procedures.
The systemic reaction rate to skin testing for aeroallergens is significant lower than the
rate of reactions to immunotherapy, but it is not negligible. Lin et al reported only 2
patients who had systemic allergic reactions to skin testing for respiratory allergies in
10,400 patients tested.3 They determined the overall risk of inducing anaphylactic reactions
by skin testing to be less than 0.02% and other studies have produced similar results.4-5
The rate of systemic reactions to skin testing is likely underscored. Thompson et. al
reported a systemic reaction rate of 6% of patients receiving skin testing.6 It is important
to recognize the risk of systemic reactions seeing skin testing is commonly done. It is also
imperative to recognize the treatments for these reactions to prevent progression.
Hypothesis The systemic reaction rate to allergen immunotherapy and skin testing to
aeroallergens is higher than previously reported. Biphasic anaphylactic reactions rarely
occur with allergen immunotherapy and skin testing.
Status | Completed |
Enrollment | 100 |
Est. completion date | June 2007 |
Est. primary completion date | June 2007 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice. Exclusion Criteria: - NON Male and female subjects who are receiving skin testing or allergen immunotherapy from one allergy practice. |
Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
United States | USF | Tampa | Florida |
Lead Sponsor | Collaborator |
---|---|
University of South Florida |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | This is a prospective observational study of patients who are having either skin testing or allergen immunotherapy for the diagnosis or treatment of allergic rhinitis, conjunctivitis, and/or asthma. | UNKNOWN | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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