SYSTEMIC REACTION Clinical Trial
Official title:
Systemic Reactions to Allergen Immunotherapy Amd Skin Testing
Allergy skin tests and allergen immunotherapy are common procedures for both the diagnosis
and treatment of atopic diseases. Allergen immunotherapy has proved to be effective in
reducing the symptoms of allergic rhinitis and asthma1-2. Despite its clinical benefit,
there is risk of systemic reactions associated with these procedures.
The systemic reaction rate to skin testing for aeroallergens is significant lower than the
rate of reactions to immunotherapy, but it is not negligible. Lin et al reported only 2
patients who had systemic allergic reactions to skin testing for respiratory allergies in
10,400 patients tested.3 They determined the overall risk of inducing anaphylactic reactions
by skin testing to be less than 0.02% and other studies have produced similar results.4-5
The rate of systemic reactions to skin testing is likely underscored. Thompson et. al
reported a systemic reaction rate of 6% of patients receiving skin testing.6 It is important
to recognize the risk of systemic reactions seeing skin testing is commonly done. It is also
imperative to recognize the treatments for these reactions to prevent progression.
Hypothesis The systemic reaction rate to allergen immunotherapy and skin testing to
aeroallergens is higher than previously reported. Biphasic anaphylactic reactions rarely
occur with allergen immunotherapy and skin testing.
n/a
Time Perspective: Retrospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05028361 -
Simultaneous mRNA COVID-19 and IIV4 Vaccination Study
|
Phase 4 |