Chronic Myelomonocytic Leukemia Clinical Trial
Official title:
Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes
This trial is for various types of malignancies which may depend on certain enzymes (tyrosine kinases) for growth. The objective of this study is to assess to what extent imatinib mesylate blocks these enzymes and to assess the effect on the malignancy.
Condition
Diverse malignancies either associated with or thought to be associated with activated
tyrosine kinase enzymes including hypereosinophilic syndrome systemic mastocytosis chronic
myelomonocytic leukaemia, dermatofibrosarcoma protuberans and other diseases.
Not included:
Patients with chronic myeloid leukemia, some other types of leukemias (abl-mutated) some
types of gastrointestinal stromal tumours (c-KIT-positive), some systemic mastocytosis (if
c-KIT D816V mutation), brain, prostate, breast or lung cancers.
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