Clinical Trials Logo

Clinical Trial Summary

Background: lupus is a heterogeneous autoimmune disease with autoantibodies formation. Lupus nephritis carries the worst prognosis. C1q deficiency correlates with activity and renal involvement and may help in its evaluation. Therapies include plasma exchange, immune adsorption and recently under evaluation, hemodiafiltration with on-line endogenous re infusion (HFR), in addition to traditional immunosuppressive therapies. Aim: is to evaluate the role of HFR in improving signs and symptoms of SLE activity and laboratory parameters not responding to traditional immune suppressive therapy


Clinical Trial Description

Settings and design: A controlled clinical study was conducted on group A, sixty patients with lupus in activity subdivided into cases 1, 47 patients, who received traditional medical treatment and cases 2 group, 13 patients, who underwent HFR in addition to medical treatment. And group B that consisted of two subgroups, control 1, 20 healthy age and sex matched volunteers and control 2, 10 cases with different glomerular diseases other than lupus.

Methods and materials: Serum c1q was done before and after the HFR as well as induction by medical treatment. Disease activity assessed using SLEDAI-2K with responder index - 50, quality of life assessed using SLEQOL v2, and HFR was performed for the non-responder group.

The study will be conducted in Alexandria University Hospitals in compliance with the Declaration of Helsinki; the ethical committee of the investigator's faculty will be requested to approve the protocol and the patients will be requested to give informed consent. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04108611
Study type Interventional
Source University of Alexandria
Contact
Status Completed
Phase N/A
Start date January 1, 2019
Completion date September 25, 2019

See also
  Status Clinical Trial Phase
Completed NCT03749044 - ASA Patterns for Prevention of Preeclampsia in SLE Pregnancies N/A
Completed NCT03218033 - Use of Social Media to Improve Medication Adherence in Adolescents and Young Adults With Systemic Lupus N/A
Not yet recruiting NCT03752983 - Chemokine (CXCL13) as Anew Marker in Diagnosis of SLE
Recruiting NCT03819777 - Volatile Organic Compounds (VOCs) as a Biomarker in Immune-mediated Pulmonary Arterial Hypertension (PAH)
Recruiting NCT04894253 - Immune Response to SARS-CoV-2 Vaccination in Systemic Lupus
Not yet recruiting NCT03164720 - SSerum/Urinary Monocyte Chemoattractant Protein-1 Level as a Marker for Lupus Nephritis
Completed NCT03762824 - Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease Phase 4
Not yet recruiting NCT06435468 - Biocollection of Rare Pediatric-onset of Autoimmune and Autoinflammatory Diseases N/A
Terminated NCT01738360 - Phase 2a Study Evaluating the Arsenic Trioxide (ATO) in Systemic Lupus (SLE) (Protocol LUPSENIC) Phase 2
Completed NCT03430388 - Yellow Fever Vaccine in Patients With Rheumatic Diseases N/A
Not yet recruiting NCT04256577 - Serum Ceramides Level in Systemic Lupus Erythematosus (SLE) Patients as a Novel Marker for Renal Impairment
Completed NCT03540823 - Evaluation of Influenza A/H3N2 Vaccine in Patients With Rheumatologic Diseases Phase 4