Systemic Lupus Erythematosus Clinical Trial
Official title:
Evaluation of Janus Kinase_3 Expression in Juvenile Onset Systemic Lupus Erythematosus
One of the best understood mechanisms by which cytokines activate signals, thus eliciting
specific responses in target cells, involves enzymes such as Janus kinases (JAKs) and
transcriptional factors such as signal transducers and activators of transcription (STATs).
For immune mediated diseases, both activating and inactivating mutations of JAKs and STATs
may cause abnormalities in immune homeostasis. Polymorphisms of JAK/STAT genes have been
linked to susceptibility for rheumatoid arthritis (RA) , systemic lupus erythematosus (SLE),
psoriatic arthritis (PA) and inflammatory bowel disease (IBD) .
Janus_kinase 3 expression will be evaluated in the serum and renal tissue of lupus patients
during active stage of the disease through this study
Investigators will assess the relationship between the expression of Janus_kinase 3 and the clinical and laboratory parameters of disease activity . Disease activity will be assessed through the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Also, investigators will evaluate the relationship between Janus_ kinase 3 expression and histopathological classes of lupus nephritis according to the 2003 International Society of Nephrology/ Renal Pathology Society (ISN/RPS) classification of lupus nephritis. This will be done through Janus_kinase 3 assessment in the blood and renal tissue of lupus patients. ;
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