Systemic Lupus Erythematosus Clinical Trial
Official title:
Study of Catalytic Antibodies in a Cohort Population of Martinique
- The Martinique island (French West-Indies) is an area of high prevalence and incidence
for Systemic Lupus Erythematosus (SLE), respectively 64,2/ 100000 and 4,7/ 100000. In
many cases, this disease concerns Afro Caribbean women, whose auto-antibodies are
excessively high; also, organic damages are frequent. The disease can be fatal.
- Studies have shown that some cytotoxic auto-antibodies may have a responsibility in the
hydrolysing of DNA. This study will focus on the DNA activity and also on the overwhelm
hydrolase activity dealing with the Lupus disease in order to measure the link between
the disease activity and the catalytic activity. Patients concerned by this study will
be Martinique people.
This study will be conducted as an case-control survey.
- The first group with patients: 60 SLE patients, 30 patients with a quiescent lupus and
30 patients with an active lupus. Patients that will be included are followed by the
University hospital of Fort-de-France.
- The second group is the control group: subjects will be recruited by the French
organisation responsible for donation of blood.
Test will be done at the UMRS 872 laboratory of the INSERM - Laboratory of Immunopathology
and Therapeutic immunointervention - in Paris ; two catalytic activities will be tested: the
DNase activity and the hydrolase activity.
Means to analyse the two activities: digestion of plasmid and Affinity-linked
Oligonucleotide Nuclease Assay for DNase activity and hydrolysis of a peptide PFR-MCA for
hydrolase activity.
;
Observational Model: Case Control, Time Perspective: Prospective
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