Hydrocephalus Clinical Trial
Official title:
Establishing the Physiology of Syringomyelia
The brain and spinal cord are surrounded by fluid called cerebrospinal fluid (CSF). The CSF
flows through channels in the brain and around the spinal cord. Occasionally, people are born
with malformations of these channels. Syringomyelia is a pocket within the CSF channels that
results from abnormal CSF flow. Syringomyelia is associated with problems in the nervous
system. Patients with syringomyelia may be unable to detect sensations of pain and heat. If
the condition is not treated it can worsen.
Treatment of this condition is surgical. It requires that the flow of CSF is returns to
normal. There are many different treatment options, but no one procedure has been shown to be
significantly better than any other.
In this study, researchers would like to learn more about how the CSF pressure and flow
contribute to the progression of syringomyelia. Ultrasounds and magnetic resonance imaging
(MRI) will be used to evaluate the anatomy of the brain. Researchers hope that information
gathered about anatomy and measures of CSF pressure and flow can be used later to develop an
optimal surgical treatment for syringomyelia.
The purpose of this study is to establish the mechanism of development and progression of
syringomyelia. Although syringomyelia usually accompanies anatomic abnormalities at the
craniocervical junction, the pathophysiology that relates these anatomic abnormalities to
syringomyelia development and progression is controversial. We have been testing the
hypothesis that progression of syringomyelia associated with the Chiari I malformation is
produced by the cerebellar tonsils partially occluding the subarachnoid space at the foramen
magnum and acting as a piston on the partially enclosed spinal subarachnoid space, creating
enlarged cervical subarachnoid pressure waves which compress the spinal cord from without,
not from within, and propagate syrinx fluid caudally with each heartbeat, which leads to
syrinx progression. We are also testing the hypothesis that development of syringomyelia
results from increased transit of CSF through the spinal cord parenchyma and into the syrinx.
Patients are treated with posterior fossa craniectomy, upper cervical laminectomy, and
duroplasty. We evaluate cerebrospinal fluid flow and pressure, syrinx size, neurologic
function, and the rate of entrance of CSF into the syrinx before and after surgery. These
studies and the intraoperative evaluation of the movement of the cerebellar tonsils and the
walls of the syrinx are providing data which elucidate the hydrodynamic mechanism of
development and progression of syringomyelia.
The best treatment for this type of syringomyelia has not been established. Present surgical
treatment results in disease stabilization in many, but not all patients, although objective
improvement is less common. Delayed deterioration is not uncommon. Correlation of the
anatomic and physiologic measurements should provide data which indicate the mode of
development and progression of syringomyelia and which may have implications for the optimal
treatment of syringomyelia.
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